Antioxidant activity of 5-hydroxytryptophan, 5-hydroxyindole, and DOPA against microsomal lipid peroxidation and its dependence on vitamin E

Free Radical Research Communications
E CadenasH Sies

Abstract

The antioxidant capacity of 5-hydroxy-tryptophan, 5-hydroxy-indole, and DOPA (3,4-dihydroxy-phenylalanine) was tested in the Fe-induced lipid peroxidation of liver microsomes of normal- and vitamin E-deficient rats, using ascorbate as a reductant. Lipid peroxidation was monitored as low-level chemiluminescence, indicative of generation of electronically-excited states arising from the recombination of secondary lipid peroxyl radicals. The lag phase (tau 0) preceding the rise in chemiluminescence intensity was used as indicator of antioxidant efficiency, in the absence (tau 0) and the presence (tau) of these polar compounds. The increase in duration of the lag phase exerted by these hydroxy compounds was expressed and quantified as the relationship: tau-tau 0. The tau-tau 0 values were considerably higher in the presence of vitamin E and almost negligible in the absence of tocopherol. It is postulated that the observed increased protection against lipid peroxidation by the above 5-hydroxy derivatives is displayed in a fashion dependent on the presence of vitamin E and probably involving recovery of the chromanoxyl radical by means of an electron-transfer process.

References

Jul 1, 1976·Lipids·S L TaylorA L Tappel
Jan 1, 1985·Annual Review of Nutrition·P B McCay
Jan 1, 1988·Basic Life Sciences·S V Jovanovic, M G Simic
Jul 1, 1987·Chemistry and Physics of Lipids·E Niki
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R KohenB N Ames
Feb 15, 1983·Archives of Biochemistry and Biophysics·G W BurtonK U Ingold
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·B N AmesP Hochstein

❮ Previous
Next ❯

Citations

Sep 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·L H JonesJ C Freitas
Oct 23, 2009·The Journal of Membrane Biology·M C Reyes-GonzalesJ J García
Nov 3, 1992·Biochemical Pharmacology·A I CederbaumH Speisky
Jan 1, 1985·Advances in Enzyme Regulation·E Cadenas, H Sies
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S ChristenR Stocker
Apr 23, 2010·Biological & Pharmaceutical Bulletin·Sung Jin BaeHae Young Chung
Feb 18, 2010·International Journal of Molecular Sciences·Sergio Millán-PlanoJoaquín J García
Jan 1, 1991·Free Radical Research Communications·E A LissiL A Videla
Sep 15, 1998·Free Radical Research·E Cadenas, H Sies
Dec 25, 2004·Journal of Pineal Research·Christian Keithahn, Alexander Lerchl
Mar 6, 2007·Medical Hypotheses·Antoaneta ZhelevaVesselina Gadzheva
Sep 15, 2010·Environmental and Molecular Mutagenesis·King-Thom Chung, Gopi S Gadupudi
Feb 25, 2006·Neurochemistry International·Luciane Rosa FeksaClovis Milton Duval Wannmacher
Oct 1, 1990·Biochemical Pharmacology·V Narayanaswami, H Sies
Aug 13, 2011·Pharmacology, Biochemistry, and Behavior·Basel A Abdel-Wahab, Ragaa H Salama
Nov 2, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Annia GalanoRussel J Reiter
Apr 22, 2008·Metabolic Brain Disease·Luciane Rosa FeksaClóvis Milton Duval Wannmacher

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Andrea CornelioClovis Milton Duval Wannmacher
Neurochemistry International
Luciane Rosa FeksaClovis Milton Duval Wannmacher
© 2022 Meta ULC. All rights reserved