Antioxidant activity of flavonoids in isolated mitochondria

Phytotherapy Research : PTR
Daniel J DortaCarlos Curti

Abstract

Mitochondria are important intracellular sources and targets of reactive oxygen species (ROS), while flavonoids, a large group of secondary plant metabolites, are important antioxidants. Following our previous study on the energetics of mitochondria exposed to the flavonoids quercetin, taxifolin, catechin and galangin, the present work addressed the antioxidant activity of these compounds (1-50 micromol/L) on Fe(2+)/citrate-mediated membrane lipid peroxidation (LPO) in isolated rat liver mitochondria, running in parallel studies of their antioxidant activity in non-organelle systems. Only quercetin inhibited the respiratory chain of mitochondria and only galangin caused uncoupling. Quercetin and galangin were far more potent than taxifolin and catechin in affording protection against LPO (IC(50) = 1.23 +/- 0.27 and 2.39 +/- 0.79 micromol/L, respectively), although only quercetin was an effective scavenger of both 2,2-diphenyl-1-picrylhydrazyl (DPPH) and superoxide radicals. These results, together with the previous study, suggest that the 2,3-double bond in conjugation with the 4-oxo function in the flavonoid structure are major determinants of the antioxidant activity of flavonoids in mitochondria, the presence of an o-di-OH s...Continue Reading

References

Jan 1, 1978·Methods in Enzymology·J A Buege, S D Aust
Oct 1, 1976·FEBS Letters·K E Akerman, M K Wikström
Mar 1, 1988·Biochemical Pharmacology·J Robak, R J Gryglewski
Dec 30, 1981·Biochimica Et Biophysica Acta·H Terada
Oct 1, 1995·Free Radical Biology & Medicine·A SaijaF Castelli
Jan 1, 1996·Free Radical Biology & Medicine·C A Rice-EvansG Paganga
Oct 17, 1998·Biochemical Pharmacology·S A van AckerW J van der Vijgh
May 17, 2000·FEBS Letters·F A van AckerA Bast
Aug 5, 2000·Journal of Natural Products·P G Pietta
Jun 21, 2001·Journal of Agricultural and Food Chemistry·S Burda, W Oleszek
Sep 19, 2002·The Journal of Biological Chemistry·Julie St-PierreMartin D Brand
Nov 28, 2002·Pharmacology & Therapeutics·Bent H Havsteen
Feb 21, 2003·Free Radical Research·M Manuela SilvaLurdes Mira
Dec 14, 2004·Free Radical Biology & Medicine·Paul S Brookes
Apr 21, 2005·Chemico-biological Interactions·Daniel J DortaCarlos Curti
Aug 22, 2006·Phytochemistry·Ameha SeyoumFathy Kandeel El-Fiky

❮ Previous
Next ❯

Citations

Apr 15, 2009·Journal of Bioenergetics and Biomembranes·Martin Modrianský, Eva Gabrielová
Mar 20, 2010·Journal of Bioenergetics and Biomembranes·Giedre BaliutyteAdolfas Toleikis
Dec 15, 2010·Journal of Bioenergetics and Biomembranes·Eva GabrielováMartin Modrianský
Aug 6, 2009·The American Journal of Chinese Medicine·Tien-Ning ChangYuan-Shiun Chang
Jun 1, 2014·Fitoterapia·A Zholobenko, M Modriansky
May 26, 2012·Phytotherapy Research : PTR·S TrumbeckaitėV Janulis
Sep 26, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joyce C MelloTiago Rodrigues
Jun 25, 2015·Oxidative Medicine and Cellular Longevity·Lina M RuizAlvaro A Elorza
Oct 29, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lijuan SuHui Luo
Nov 29, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Natalia S S GuimarãesTiago Rodrigues
Sep 22, 2009·Environmental Pollution·Niina M M SavirantaReijo O Karjalainen
Feb 4, 2014·Biochimica Et Biophysica Acta·Ester CasanovaM Josepa Salvadó
Mar 1, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yuhan TangPing Yao
Nov 21, 2009·Medicine and Science in Sports and Exercise·David C NiemanDru A Henson
Sep 19, 2019·CNS & Neurological Disorders Drug Targets·Ambreen Fatima, Yasir Hasan Siddique
Jul 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria Assunta PotenzaMonica Montagnani
Jan 24, 2019·Nutrients·Ilenia BazzucchiFrancesco Felici
Sep 16, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Joana Varlla de Lacerda AlexandreHeberty Tarso Facundo
Jul 4, 2009·Journal of Agricultural and Food Chemistry·Hong-Yu LinWenchang Chiang
Sep 8, 2019·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Stephane Janaina de Moura EscobarMaria Eliane Merlin Rocha
Aug 19, 2021·Molecular and Cellular Biochemistry·Artem G VeikoIlya B Zavodnik

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.