Antioxidant activity of oligosaccharide ester extracted from Polygala tenuifolia roots in senescence-accelerated mice

Pharmaceutical Biology
Ping LiuDong-Xiao Wang

Abstract

The constituents of the ethanol extract from the root of Polygala tenuifolia Willd. (Polygalaceae) were investigated for antioxidant activity in senescence-accelerated mice. Consequently, two relevant samples were obtained, a fraction separated by macroporous resin (YZ-OE), and a major pure crystal of 3,6'-disinapoyl sucrose (DISS). Based on HPLC-ESI-MS analysis, the most constituents in the YZ-OE fraction from the extract of P. tenuifolia were oligosaccharide esters. The antioxidant activities of these two samples were evaluated using the accelerated senescence-prone, short-lived mice (SAMP) in vivo. The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) were increased significantly in SAMP mice fed oligosaccharide esters (YZ-OE 50 mg/kg) and its constituents (DISS 50 mg/kg). However, the content of malondialdehyde (MDA) was increased in the blood and liver of SAMP mice. But when given YZ-OE, it could be decreased, by 44.3% and 47.5%, respectively, compared with the SAMP model. Results from the analyses indicated that the oligosaccharide esters (YZ-OE) from roots of P. tenuifolia had a high in vivo antioxidant activity.

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Citations

May 19, 2011·The Journal of Pharmacy and Pharmacology·Yuan HuKhalid Rahman
May 28, 2011·Biomedical Chromatography : BMC·Yun LingChenggang Huang
Sep 1, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Lu XuPing Liu
Mar 18, 2015·Journal of Photochemistry and Photobiology. B, Biology·P C NagajyothiHeung Mook Shin
Apr 11, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Xiang-Yang ChenBin Liu
Jun 2, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Wu ZengBetty Yuen Kwan Law

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