Antioxidant and ACE Inhibitory Activity of Enzymatic Hydrolysates from Ruditapes philippinarum

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Yue YuMing Du

Abstract

Ruditapes philippinarum proteins were hydrolyzed by trypsin, neutrase, and pepsin. The antioxidant activities and ACE inhibitory activity of hydrolysates were analyzed and the antioxidant activities were related to their molecular weight distribution and amino acid compositions. Results indicated the hydrolysis of proteins led to an increase in small peptides and free amino acids. The antioxidant activities of Ruditapes philippinarum hydrolysates against DPPH radical scavenging, inhibition on linoleic acid peroxidation, and reducing power showed that the neutrase hydrolysate exhibited the strongest antioxidant activity. In addition, an ACE inhibition assay revealed that the pepsin hydrolysate had the highest ACE inhibitory ability. Ruditapes philippinarum protein hydrolysates could be a promising source of natural antioxidant and ACE inhibitory.

References

Mar 2, 1972·The New England Journal of Medicine·H R BrunnerF R Bühler
Jul 1, 1971·Biochemical Pharmacology·D W Cushman, H S Cheung
Aug 7, 1967·Biochemical and Biophysical Research Communications·J Feder, C Lewis
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·B N AmesT M Hagen
Feb 18, 1999·Toxicology Letters·B N Ames
Apr 1, 2000·The Journal of Nutritional Biochemistry·K SuetsunaH Ochi
May 29, 2003·Journal of Agricultural and Food Chemistry·Ai SaigaToshihide Nishimura
Feb 19, 2004·Journal of Agricultural and Food Chemistry·Kazunori KatayamaMichio Muguruma
Mar 23, 2004·Molecular & Cellular Proteomics : MCP·Jesper V OlsenMatthias Mann
Jan 5, 2005·BioFactors·Hans Meisel
Aug 24, 2005·The Journal of Nutritional Biochemistry·Niranjan RajapakseSe-Kwon Kim
Feb 13, 2007·Current Opinion in Biotechnology·Rainer Hartmann, Hans Meisel
Dec 11, 2007·Journal of Proteome Research·Jesse RodriguezPavel A Pevzner
Mar 6, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Seung-Jae LeePyo-Jam Park

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Citations

Aug 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yiqi ZhangZhiyuan Dai

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Methods Mentioned

BETA
Assay

Software Mentioned

OpenLAB CDS
SPSS
Agilent Quantitative Analysis

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