Mar 29, 2014

Antioxidant and anti-inflammatory activities of berberine in the treatment of diabetes mellitus

Evidence-based Complementary and Alternative Medicine : ECAM
Zheng LiWei-Jia Kong

Abstract

Oxidative stress and inflammation are proved to be critical for the pathogenesis of diabetes mellitus. Berberine (BBR) is a natural compound isolated from plants such as Coptis chinensis and Hydrastis canadensis and with multiple pharmacological activities. Recent studies showed that BBR had antioxidant and anti-inflammatory activities, which contributed in part to its efficacy against diabetes mellitus. In this review, we summarized the antioxidant and anti-inflammatory activities of BBR as well as their molecular basis. The antioxidant and anti-inflammatory activities of BBR were noted with changes in oxidative stress markers, antioxidant enzymes, and proinflammatory cytokines after BBR administration in diabetic animals. BBR inhibited oxidative stress and inflammation in a variety of tissues including liver, adipose tissue, kidney and pancreas. Mechanisms of the antioxidant and anti-inflammatory activities of BBR were complex, which involved multiple cellular kinases and signaling pathways, such as AMP-activated protein kinase (AMPK), mitogen-activated protein kinases (MAPKs), nuclear factor erythroid-2-related factor-2 (Nrf2) pathway, and nuclear factor- κ B (NF- κ B) pathway. Detailed mechanisms and pathways for the antiox...Continue Reading

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Mentioned in this Paper

Pathogenic Aspects
Biochemical Pathway
Pathogenesis
Berberine
Enzymes, antithrombotic
Mitogen-Activated Protein Kinases
Natural Products
Anti-Inflammatory Agents
PRKAA2 gene
Antioxidants

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