Antioxidant and anti-inflammatory activities of alpha lipoic acid protect against indomethacin-induced gastric ulcer in rats

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Asmaa M S GomaaHazem A Aamer

Abstract

Little is known about the role of tumor necrosis factor-alpha (TNF-α), plasminogen activator inhibitor-1 (PAI-1), and inducible nitric oxide synthase (iNOS) in the gastric ulcer and the effect of alpha lipoic acid (ALA) in their modulation. Hence, this experimental study was designed to assess the possible protective effect of ALA against indomethacin (IND)-induced gastric ulcer in rats, as well as to determine the possible underlying mechanisms with a special focus on TNF-α, PAI-1, and iNOS. Adult male rats (n = 28) were divided into four equal groups: the control group received distilled water, the vehicle group received 0.5% carboxymethylcellulose, the ulcer group received a single oral dose of IND (50 mg/kg) and the ALA-treated group received ALA (100 mg/kg) orally for 3 days before ulcer induction. Four hours after IND administration, all rats were sacrificed. The ulcer index, and gastric tissue homogenate contents of total antioxidant capacity (TAC), malondialdehyde (MDA), TNF-α, and PAI-1 were evaluated. Immunohistochemical evaluation of iNOS protein expression and histopathological examination of gastric tissue were investigated. The results revealed that ALA pretreatment significantly decreased the ulcer index, the gas...Continue Reading

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Citations

Sep 6, 2020·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Özlem ÖzdemirHasan Turkez
Mar 19, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Jun ZhangBi-Wei Song
May 31, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Jia-Cheng ShenZong-Bao Yang
Jan 18, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Qi-da HeZong-Bao Yang
Oct 7, 2020·Clinical and Experimental Pharmacology & Physiology·Gisele Maziero AlvesBianca Prandi Campagnaro
Jan 12, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Fatemeh Sadat MahdaviMahboobeh Mehrabani-Natanzi
Nov 3, 2020·Molecular Biology Reports·Yasin DuranAhsen Yılmaz
Jun 3, 2021·Animals : an Open Access Journal From MDPI·Reshma M AnthonyKathy L Gross

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