Antioxidant and anti-inflammatory effects of flavocoxid in high-cholesterol-fed rabbits

Naunyn-Schmiedeberg's Archives of Pharmacology
Ahmed R El-SheakhEl-Sayed M Ammar

Abstract

Flavocoxid is a mixed extract containing baicalin and catechin, and it acts as a dual balanced inhibitor of cyclooxygenase-1 (COX-1) and COX-2 peroxidase enzyme activities with a significant inhibition of 5-lipoxygenase (5-LOX) enzyme activity in vitro. Flavocoxid downregulates gene or protein expression of several inflammatory markers and exerts also strong antioxidant activity in several experimental models. Inflammation and oxidative stress contribute in the pathogenesis of atherosclerosis. In the present study, an experimental rabbit model of hypercholesterolemia was developed and the effects of flavocoxid were evaluated. Rabbits were divided into four groups-normal control, high-cholesterol-diet (HCD)-fed group, HCD plus flavocoxid (20 mg/kg/day), or HCD plus atorvastatin (10 mg/kg/day). Blood samples were collected at the end of the experiment for measuring serum total cholesterol (TC), triglycerides (TGs), high-density lipoprotein cholesterol (HDL-C), C-reactive protein (CRP), malondialdehyde (MDA), reduced glutathione (GSH), and superoxide dismutase (SOD). In addition, the aorta was removed for measurement of antioxidant status, vascular reactivity, and intima/media (I/M) ratio. Elevated levels of serum TC, TGs, LDL-C, ...Continue Reading

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Citations

Dec 23, 2016·Medicinal Research Reviews·Catarina Pereira-LeiteSalette Reis
Feb 29, 2020·Drug Design, Development and Therapy·Eman Ebrahim El NaggarMohammed Fawzy Hamed
Feb 23, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Likun CuiLongquan Xiang
Aug 26, 2021·Environmental Science and Pollution Research International·Nagwa I MohamedGhada M Suddek

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