Antioxidant and anti-inflammatory nutrient status, supplementation, and mechanisms in patients with schizophrenia

Progress in Neuro-psychopharmacology & Biological Psychiatry
Sumedha MitraXiaoduo Fan

Abstract

Over 50 million people around the world suffer from schizophrenia, a severe mental illness characterized by misinterpretation of reality. Although the exact causes of schizophrenia are still unknown, studies have indicated that inflammation and oxidative stress may play an important role in the etiology of the disease. Pro-inflammatory cytokines are crucial for normal central nervous development and proper functioning of neural networks and neurotransmitters. Patients with schizophrenia tend to have abnormal immune activation resulting in elevated pro-inflammatory cytokine levels, ultimately leading to functional brain impairments. Patients with schizophrenia have also been found to suffer from oxidative stress, a result of an imbalance between the production of free radicals and the ability to detoxify their harmful effects. Furthermore, inflammation and oxidative stress are implicated to be related to the severity of psychotic symptoms. Several nutrients are known to have anti-inflammatory and antioxidant functions through various mechanisms in our body. The present review evaluates studies and literature that address the status and supplementation of omega-3 polyunsaturated fatty acids, vitamin D, B vitamins (B6, folate, B12...Continue Reading

References

Dec 1, 2010·Asian Journal of Psychiatry·Tze Jen ChowPek Yee Tang
Sep 24, 2013·Revista de psiquiatrí́a y salud mental·Daniela NunesIngrid Dalira Schweigert Perry

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Citations

Mar 14, 2019·The Australian and New Zealand Journal of Psychiatry·Myeongju ChoJun Soo Kwon
May 20, 2020·Journal of Clinical Pharmacology·Tengfei YuanYan Li
Jul 12, 2020·International Journal of Molecular Sciences·Maria LucaAntonina Luca
Oct 22, 2020·Brain Sciences·Samskruthi Madireddy, Sahithi Madireddy
Jul 22, 2019·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Claudia Juárez-PortillaRossana C Zepeda
Nov 19, 2020·Clinical Nutrition Research·Hee Yun Cha, Soo Jin Yang
Jan 14, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Sélim Benjamin GuessoumJasmina Mallet
Jul 27, 2021·Journal of Biochemical and Molecular Toxicology·Ismet Burcu TurkyilmazRefiye Yanardag
Aug 10, 2021·Frontiers in Psychiatry·Alex J MurrayRachel Upthegrove

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