Antioxidant and anti-inflammatory properties of Taiwanese yam (Dioscorea japonica Thunb. var. pseudojaponica (Hayata) Yamam.) and its reference compounds

Food Chemistry
Chuan-Sung ChiuGuan-Jhong Huang

Abstract

Dioscorea japonica Thunb. var. pseudojaponica (DP) is consumed as food and widely used in traditional Chinese medicine in Taiwan. The aims of this study are to investigate the antioxidant and anti-inflammatory effects of ethanol extract of DP (EDP) and its reference compounds. Fingerprint chromatogram from HPLC indicated that EDP contains gallic acid and vanillic acid. EDP was evaluated for its antioxidant effects and LPS-induced nitrite oxide (NO) production in RAW264.7 cells. EDP decreased the LPS-induced NO production and expressions of iNOS and COX-2 in RAW264.7 cells. In-vivo anti-inflammatory activities of EDP were assessed in mouse paw oedema induced by λ-carrageenan (Carr). We investigated the antioxidant mechanism of EDP via studies of the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) and the levels of malondialdehyde (MDA) in the oedematous paw. The results showed that EDP might be a natural antioxidant and anti-inflammatory agent.

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Citations

Nov 10, 2013·Journal of Agricultural and Food Chemistry·Guan-Jhong HuangYueh-Hsiung Kuo
Jun 15, 2016·Chinese Journal of Integrative Medicine·Shin-da LeeChih-Yang Huang
Jul 17, 2016·BMC Complementary and Alternative Medicine·Seong Eun JinSoo-Jin Jeong
Dec 22, 2016·Journal of Agricultural and Food Chemistry·Zhuo QuWenyuan Gao
Mar 10, 2017·Pharmaceutical Biology·Peidong ChenAnwei Ding
Sep 20, 2020·Foods·Jude E ObidiegwuCynthia A Chilaka
Oct 11, 2017·Journal of Food and Drug Analysis·Chih-Tai ChenJing-Hsien Chen
Sep 23, 2020·Planta·Janina Epping, Natalie Laibach
Dec 13, 2019·BMC Complementary and Alternative Medicine·Kumpei TakahashiMasahiro Itoh

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