Antioxidant and Anti-Inflammatory Properties of an Extract Rich in Polysaccharides of the Mushroom Polyporus dermoporus

Antioxidants
Celina Maria P Guerra DoreEdda Lisboa Leite

Abstract

Polyporus dermoporus mushroom, native to Brazil, is produced under natural conditions in the unexplored reserve of Mata da Estrela-Rio Grande do Norte-RN. These mushrooms were delipidated with chloroform:methanol (2:1 v/v), extracted with water at 100 °C, and fractionated with ethanol (one and three volumes) and then centrifuged. The ethanol precipitation showed a high total sugar level of 64.8% and 1% of protein. This precipitate contained a high glucan level, characterized by chemical methods and by NMR of (13)C and ¹H and spectroscopy. The (13)C NMR spectrum of these mushroom extracts showed the presence of β-glucose by a signal at 103.25 ppm. Studies with these glucans were made to elucidate antioxidant and anti-inflammatory activities. This extract of glucans inhibited the lipid peroxidation (42.9%) and superoxide radicals (83.3%) at 67 μg/mL. However, the inhibition of hydroxyl radical by the extract of this mushroom was 96% at 267 μg/mL. The action of this extract on induced pleurisy showed a 92.5% and 68.7% reduction in polymorphonuclears cells and nitric oxide, respectively, at 30 mg/kg. The glucans reduced the croton oil-induced ear edema by 65.6% at 30 mg/kg.

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Citations

Mar 4, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ningbo LiaoRonghua Zhang
Jan 10, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Huijuan JingLe Jia
Oct 17, 2020·International Journal of Biological Macromolecules·Gülsen Tel-ÇayanMehmet Öztürk

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Methods Mentioned

BETA
biopsies
NMR

Software Mentioned

GraphPad Prism
GraphPad

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