Antioxidant and Antiapoptotic effect of aqueous extract of Pueraria tuberosa (Roxb. Ex Willd.) DC. On streptozotocin-induced diabetic nephropathy in rats

BMC Complementary and Alternative Medicine
Rashmi ShuklaYamini B Tripathi

Abstract

Oxidative stress and renal apoptosis play a significant role in the progression of diabetic nephropathy. The tubers of Pueraria tuberosa (Roxb. ex Willd.) DC. has been traditionally used as anti-ageing and health promotive tonic. The purpose of this study was to investigate its nephroprotective effect and mechanism via antioxidant and antiapoptotic potential in Streptozotocin-induced diabetic nephropathy (DN) in rats. The chemical composition of aqueous extract of Pueraria tuberosa (PTY-2r) was analyzed by gas chromatography-mass spectrometry (GC-MS). Diabetes was induced by intraperitoneal injection of streptozotocin (STZ) (55 mg/kg body weight) in rats. After 60 days, the rats were randomly divided into 3 groups (n = 6/each group), namely DN control (DN) group-2, DN rats treated with PTY-2r at the dose of 50 mg/100 g, group-3 and 100 mg/100 g, group-4 p.o. for 20 days. The normal rats were chosen as a normal control (NC) group-1. PTY-2r was orally given to the rats for 20 days. Reactive oxygen species (ROS), lipid peroxidation (LPO) and the activity of ROS-scavenging enzymes - superoxide dismutase (SOD), catalase (CAT) & glutathione peroxidase (GPx) were determined in the kidney tissue of DN rats. The expression of apoptosis-...Continue Reading

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Citations

Jun 23, 2019·BMC Complementary and Alternative Medicine·Lei QiYuan Lin
Oct 18, 2019·Frontiers in Endocrinology·Zhen-Ye ZhangRu-Xing Wang
Jan 16, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eunsoo JungJunghyun Kim
Mar 13, 2021·Frontiers in Pharmacology·Ram BhartiNeeraj Khatri
Mar 28, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Waleed El MalekyHekma A Abd El-Latif
Aug 27, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chen YuJia-Zhu Li
Oct 2, 2021·Journal of Animal Physiology and Animal Nutrition·Akhand ManiJeena Gupta
Aug 31, 2020·Journal of Ayurveda and Integrative Medicine·Sarvesh Kumar Singh Sanjeev Sharma

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Methods Mentioned

BETA
urine collections
urine collection
ribosylation

Software Mentioned

Image J J
LSM 510 Meta
Statistical Analysis System ( SPSS Statistics

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