Antioxidant and antibacterial polyelectrolyte wound dressing based on chitosan/hyaluronan/phosphatidylcholine dihydroquercetin.

International Journal of Biological Macromolecules
Mohamed A HassanLadislav Šoltés

Abstract

Antioxidant and antimicrobial wound dressings are the most favorable for acute and chronic wounds treatment. Herein, we formulated a multifunctional polyelectrolyte wound dressing membrane on the basis of chitosan (Ch) and hyaluronan (HA) enhanced by phosphatidylcholine dihydroquercetin (PCDQ). Physicochemical properties and microstructures of fabricated films were investigated adopting Fourier transform infrared (FT-IR) spectroscopy, thermogravimetric analysis (TGA) and scanning electron microscope (SEM). Furthermore, water uptakes, wettability profiles, surface roughness, and mechanical characteristics of the developed membranes were studied. The developed wound dressing revealed free radical scavenging potency, hemocompatibility with a tendency to enhance blood clotting. Furthermore, incorporation of PCDQ significantly promoted the antibacterial and anti-inflammatory activities of Ch/HA/PCDQ. Moreover, Ch/HA/PCDQ films exhibited cellular compatibility towards mouse fibroblast cells. The capability of Ch/HA/PCDQ to promote wound healing was evaluated using adult Wistar albino female rats. The in vivo findings demonstrated that Ch/HA/PCDQ films significantly ameliorated mouse full-thickness wounds as evidenced by a reduction i...Continue Reading

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Citations

Jan 21, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ahmed M OmerMark A T Blaskovich
Dec 29, 2020·International Journal of Biological Macromolecules·Maryam ShafiqueSyed Ahmed Shah
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Katarína Valachová, Ladislav Šoltés
Mar 8, 2021·International Journal of Biological Macromolecules·Yuanxi XiaoJinfeng Ni
Apr 4, 2021·Journal of Tissue Viability·Lucia Melguizo-RodríguezConcepción Ruiz
Apr 24, 2021·International Journal of Biological Macromolecules·Yan PengZhi Li
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Katarína Valachová, Ladislav Šoltés
Jun 27, 2021·International Journal of Biological Macromolecules·Mohammed ElhagMohamed M El Sadek
Jul 12, 2021·International Journal of Biological Macromolecules·K MohanrasuA Arun
Aug 7, 2021·Life·Lucas Fernando Sérgio GushikenCláudia Helena Pellizzon
Aug 22, 2021·International Journal of Biological Macromolecules·Jean Lucas TanakaNatan Roberto de Barros

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