Antioxidant and anticancer properties and mechanisms of inorganic selenium, oxo-sulfur, and oxo-selenium compounds

Cell Biochemistry and Biophysics
Ria R Ramoutar, Julia L Brumaghim

Abstract

Inorganic selenium and oxo-sulfur compounds are widely available in dietary supplements and have been extensively studied for their antioxidant and anticancer properties. Although many in vivo and clinical trials have been conducted using these compounds, their biochemical and chemical mechanisms of efficacy are the focus of much current research. This review discusses the ability of inorganic selenium compounds, such as selenite, and selenate, to prevent damage from reactive oxygen species as well as their ability to promote cell death by reactive oxygen species generation. Oxo-sulfur and selenium compounds, such as allicin, dimethyl sulfone, methionine sulfoxide, and methylselenenic acid also have similar abilities to act as both antioxidants and pro-oxidants, but the mechanisms for these behaviors are distinctly different from those of the inorganic selenium compounds. The antioxidant and pro-oxidant properties of these small-molecule sulfur and selenium compounds are extremely complex and often greatly depend on experimental conditions, which may explain contradictory literature reports of their efficacy.

References

Jan 1, 1991·Biological Trace Element Research·E O KajanderK Akerman
May 1, 1991·The American Journal of Clinical Nutrition·M P LongneckerJ S Morris
Dec 1, 1990·Biochemical Society Transactions·K F Gey
Mar 1, 1990·Agents and Actions·A N Makheja, J M Bailey
Dec 1, 1990·The American Journal of Clinical Nutrition·J B VanderpasA T Diplock
Apr 1, 1989·Biological Trace Element Research·L OlmstedJ Dowd
Apr 1, 1989·Australian Paediatric Journal·K P DawsonN Mogridge
Jul 1, 1989·The Journal of Nutrition·J G YangR F Burk
Feb 1, 1989·Nihon juigaku zasshi. The Japanese journal of veterinary science·T HiguchiH Ohishi
Sep 1, 1986·The Journal of Nutrition·M A Beilstein, P D Whanger
Jun 3, 1988·Science·J A Imlay, S Linn
Jul 1, 1987·Journal of Bacteriology·J A Imlay, S Linn
Jan 1, 1987·Journal of Cell Science. Supplement·S Linn, J A Imlay
Jan 1, 1986·Advances in Experimental Medicine and Biology·C Ip
Feb 9, 1973·Science·J T RotruckW G Hoekstra
May 1, 1983·The American Journal of Clinical Nutrition·G Q YangS Z Sun
May 1, 1983·Archives of Biochemistry and Biophysics·N Brot, H Weissbach
May 1, 1982·The American Journal of Clinical Nutrition·V R YoungM Janghorbani
Sep 1, 1981·Journal of Agricultural and Food Chemistry·T W PearsonH B Lackey
Jun 1, 1994·Chemico-biological Interactions·G N Schrauzer, J Sacher
Jul 17, 1995·Biochemical Pharmacology·J LuH Thompson
Feb 1, 1995·Planta medica·K Kumari, K T Augusti
Feb 1, 1995·Free Radical Biology & Medicine·S J Stohs, D Bagchi
Jan 1, 1994·Scandinavian Journal of Rheumatology. Supplement·E Allander
Jan 1, 1995·Free Radical Biology & Medicine·W Vogt
Jul 1, 1994·Free Radical Biology & Medicine·J E Spallholz
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·W A PryorG L Squadrito

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Citations

Jan 17, 2012·Applied Biochemistry and Biotechnology·Jing Z DongY Wang
Mar 22, 2012·Applied Biochemistry and Biotechnology·J Z DongY Wang
Dec 4, 2012·Cancer Management and Research·Vijayalakshmi ThamilselvanSivagnanam Thamilselvan
Sep 6, 2012·International Journal of Molecular Sciences·Carmen SanmartínJuan Antonio Palop
Oct 22, 2011·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Rui GusmãoMiquel Esteban
Oct 17, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Guk-Heui JoYung Hyun Choi
Jan 23, 2016·Life Sciences·Banafsheh Amir Aslani, Sirous Ghobadi
Sep 15, 2012·Biochemical and Biophysical Research Communications·Choon Young KimKee-Hong Kim
May 29, 2012·Journal of Photochemistry and Photobiology. B, Biology·Shohreh NafisiFirouzeh Manouchehri
Jun 21, 2012·Journal of the Science of Food and Agriculture·Jing Z DongMing Z Zhang
Jun 19, 2013·Experimental Cell Research·Takanori TsukamotoHiroyuki Tsuchiya
Nov 28, 2013·Journal of Agricultural and Food Chemistry·Marta CalatayudDinoraz Vélez
Jul 2, 2016·Journal of the Science of Food and Agriculture·Hong HuangTianfeng Wu
Feb 16, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Nenad R FilipovićTamara R Todorović
Mar 17, 2017·Nutrients·Matthew ButawanRichard J Bloomer
Jan 11, 2017·The Journal of Toxicological Sciences·Takao TobeHideto Jinno
May 15, 2018·Antioxidants·Evangelos ZoidisGeorgios P Danezis
Nov 13, 2018·Medical Physics·Konstantinos P ChatzipapasGeorge C Kagadis
Nov 22, 2019·Metallomics : Integrated Biometal Science·Elias O U EtesholaDaniel L Morris
Jul 4, 2019·Current Pharmaceutical Design·Rama AlhasanCaroline Gaucher
Feb 3, 2011·Metallomics : Integrated Biometal Science·Erin E BattinJulia L Brumaghim
Mar 25, 2017·Antioxidants·Levon A TavadyanHakob G Tonikyan
Jan 17, 2019·Journal, Genetic Engineering & Biotechnology·Solomon A Ndoni, Tebekeme Okoko
Mar 3, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Martin M KimaniJulia L Brumaghim
Sep 30, 2018·Environmental Geochemistry and Health·Habib UllahRafay Ahmad
Feb 24, 2017·Biological Trace Element Research·Abdullah BasogluErdem Gulersoy
Dec 14, 2016·Biological Trace Element Research·Xiuwen LanYingwei Xue

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