Antioxidant and Anticholinesterase Potential of Six Thymus Species

Evidence-based Complementary and Alternative Medicine : ECAM
Marija KindlSanda Vladimir-Knezević

Abstract

The present study aimed to evaluate antioxidant and acetylcholinesterase (AChE) inhibitory activities of the ethanolic extracts of six selected Thymus species growing in Croatia (T. longicaulis, T. praecox subsp. polytrichus, T. pulegioides, T. serpyllum subsp. serpyllum, T. striatus, and T. vulgaris). Antioxidant effectiveness was assessed using six different assays, in comparison with rosmarinic acid, luteolin, and reference antioxidants. All tested Thymus extracts possessed DPPH (IC50 = 3-6 μg/mL) and nitric oxide (IC50 = 70-177 μg/mL) free radical scavenging activities, strong reducing properties (IC50 = 11-15 μg/mL), ferrous ion chelating activity (IC50 = 126-389 μg/mL), ability to inhibit lipid peroxidation (IC50 = 34-80 μg/mL), and high total antioxidant capacities (238-294 mg AAE/g). AChE inhibitory activity was examined using Ellman's colorimetric method and all tested extracts showed anti-AChE activity in a dose dependent manner. The values of 10-28%, 23-39%, and 64-86% were obtained for tested concentrations of 0.25, 0.5, and 1 mg/mL, respectively. Additionally, the contents of total hydroxycinnamic derivatives, flavonoids, and tannins in dried plant samples were determined spectrophotometrically. Our results highlig...Continue Reading

References

Aug 6, 2004·Nature·Mark P Mattson
Jun 23, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·D Venkat RatnamM N V Ravi Kumar
Jan 30, 2007·Journal of Ethnopharmacology·Sükran Kültür
Mar 10, 2007·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Pulok K MukherjeePeter J Houghton
Dec 12, 2007·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Steinthor Sigurdsson, Sigmundur Gudbjarnason
May 28, 2008·Fitoterapia·Mitra MahmoudiElham Mojra
Jul 29, 2008·Journal of Agricultural and Food Chemistry·Remigius ChizzolaChlodwig Franz
Dec 2, 2008·Journal of Cellular and Molecular Medicine·Yif'at BiranPaul A Adlard
Mar 17, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·I OrhanB Sener
Jun 9, 2009·Free Radical Biology & Medicine·Etsuo Niki
Apr 14, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Cengiz SarikurkcuEbru Mete
Sep 3, 2010·Current Neuropharmacology·Fadi Massoud, Serge Gauthier
Sep 30, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Biljana BlazekovićMaja Bival Stefan
Oct 23, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jin Dai, Russell J Mumper
Feb 12, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sanda Vladimir-KneževićJózsef Petrik
Sep 18, 2012·Neurochemistry International·Mark A GreenoughAshley I Bush
Jan 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Arif Nisha SyadPandima Devi Kasi
Oct 22, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Young-Jun LeeOk-Hwan Lee
Jan 15, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sanda Vladimir-KneževićAdelheid H Brantner
May 28, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Mahmood RasoolIshfaq Ahmed Sheikh

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Citations

Sep 1, 2017·International Journal of Molecular Sciences·Andrea F AfonsoSusana M Cardoso
Jun 23, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andrea F AfonsoSusana M Cardoso
May 26, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Fatma GuesmiAhmed Landoulsi
Jun 2, 2018·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Cristina M UrituBogdan I Tamba
May 22, 2021·Natural Product Research·Mahira MehanovićAnja Haverić
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anh Thu HaJae Youl Cho

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