Antioxidant and antihyperlipidemic activity of Costus speciosus against atherogenic diet-induced hyperlipidemia in rabbits

Journal of Integrative Medicine
Fatma Mohamed Hussein ShediwahMyrene Roselyn D'Souza

Abstract

An extract of Costus speciosus (CSE), a herb widely used in folk medicine, was evaluated for its antioxidant, antihyperlipidemic and ameliorating effects on histopathological changes in atherogenic rabbits. Twenty-four male rabbits (Oryctolagus cuniculus) were divided into 4 groups. Three groups were fed a diet containing 3% saturated fat and 1.3% cholesterol for 40 d. One of these was sacrificed on the 40th day and was called the pathogenic (P) group; the other two groups received treatment for another 30 d as follows: one received 0.8 g/(kg·d) of CSE and the other was given 0.01 g/(kg·d) of simvastatin. The normal group was sacrificed on the 70th day and used as a control. CSE showed radical-scavenging ability. Administration of CSE for a 30-day period resulted in a significant decrease in total cholesterol, triacylglycerol, low-density lipoprotein and aspartate aminotransferase compared to the P group, while levels of hemoglobin, packed corpuscular volume and red blood cells were elevated. With respect to studies performed on the heart, a decrease in malondialdehyde and an increase in reduced glutathione were noted. Total protein increased in the liver, heart and aorta after treatment with CSE and also a marked improvement i...Continue Reading

Citations

Sep 15, 2020·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Ghazaleh HeydariradMehdi Pasalar
Feb 6, 2020·Environmental Science and Pollution Research International·Mona Abdel-RahmanAhmed E Abdel Moneim
Jul 5, 2021·BMC Pharmacology & Toxicology·Khalid Mohammed NajiMyrene R D'souza

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