Antioxidant and antimicrobial activities of aporphinoids and other alkaloids from the bark of Annona salzmannii A. DC. (Annonaceae)

Natural Product Research
Emmanoel V CostaMarcos J Salvador

Abstract

The antioxidant capacity by oxygen radical absorbance capacity (ORAC)-FL method and antimicrobial activity using the broth microdilution method of aporphinoids (liriodenine 1, anonaine 2 and asimilobine 3) and other alkaloids (reticuline 4 and cleistopholine 5) isolated from the bark of Annona salzmannii A. DC. (Annonaceae) were evaluated. For antioxidant activity, the most active alkaloid was asimilobine with ORAC value of 2.09 relative trolox equivalents. For antimicrobial activity, some alkaloids showed significant minimal inhibitory concentration (MIC) values in the range of 25-100 µg mL(-1). The most active compounds were the aporphinoids liriodenine, anonaine and asimilobine, some of them more active than the positive control.

References

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Citations

Dec 26, 2015·International Journal of Molecular Sciences·Mei-Yin ChangHuei-Ping Dong
Apr 30, 2016·Oxidative Medicine and Cellular Longevity·Francisca Valéria Soares de Araújo PinhoIrwin Rose Alencar de Menezes
Feb 26, 2016·Natural Product Research·José Agustín Orozco-CastilloAlma Rosa González-Esquinca
Dec 18, 2016·Natural Product Research·N LallY Oshima
Jul 17, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hsing-Tan LiChung-Yi Chen
Oct 1, 2015·Brazilian Journal of Biology = Revista Brasleira De Biologia·R S R BenitesMs Silva
Feb 28, 2018·Medicinal Research Reviews·Xiao-Fei ShangKuo-Hsiung Lee
Apr 13, 2020·Journal of Applied Microbiology·Natalia I Di MarcoCecilia S M Lucero-Estrada
Aug 17, 2017·Anais Da Academia Brasileira De Ciências·Nícolas C C PintoRodrigo L Fabri
Dec 11, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ari Satia NugrahaPaul A Keller
Oct 29, 2020·Journal of Molecular Modeling·Adriana Pérez-GonzálezErnesto Chigo-Anota
Nov 17, 2020·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Adriele Dandara Levorato VincheRinaldo Poncio Mendes
Jan 24, 2021·Chemico-biological Interactions·Giovanna Nogueira da Silva Avelino Oliveira RochaJackson Roberto Guedes da Silva Almeida
Jul 10, 2019·Natural Product Research·Ari S NugrahaPaul A Keller
Jan 24, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Juliana M LimaQuezia B Cass
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Emmanoel V CostaDaniel P Bezerra

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