Antioxidant and cytoprotective effects of N-acetylcysteine against subchronic oral glyphosate-based herbicide-induced oxidative stress in rats

Environmental Science and Pollution Research International
Ruhi TurkmenSinan Ince

Abstract

It is claimed that oxidative stress has a prominent role in the mechanism of toxic effects formed by glyphosate-based herbicide (GBH) in living systems. A strong thiol compound, N-acetylcysteine (NAC), has antioxidative and cytoprotective properties. The objective in this subchronic toxicity study was to identify the prophylactic effect of NAC over histopathological changes and oxidative stress induced by GBH in blood, renal, liver, cardiac, and brain tissues. A sum of 28 male Wistar rats were divided into four equal groups, each containing 7 rats. During the study, group I (control group) was supplied with normal rodent bait and tap water ad libitum. The applied agents were 160 mg/kg NAC to group II, 375 mg/kg as equivalent to 1/10 of lethal dose 50% (LD50) of GBH to group III, and 160 mg/kg of NAC and 375 mg/kg of GBH together once per day as oral gavage to group IV for 8 weeks. While GBH decreased the levels of GSH in blood, liver, kidney, and brain tissues, it considerably increased malondialdehyde levels. On the contrary, these parameters happened to improve in the group supplied with NAC. Besides, it was seen that NAC was observed to improve the histopathologic changes in rat tissues induced by GBH. It was concluded that ...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jan 1, 1990·Methods in Enzymology·H H Draper, M Hadley
May 1, 1985·Canadian Journal of Physiology and Pharmacology·L W WhitehouseG Solomonraj
Nov 1, 1967·The American Review of Respiratory Disease·G A HurstC A LeMaistre
Jul 23, 1983·British Medical Journal·L F Prescott
Jan 1, 1984·Methods in Enzymology·H Aebi
Dec 14, 1999·Bulletin of Environmental Contamination and Toxicology·E YarsanA Aydin
Jun 17, 2004·Drug and Chemical Toxicology·Sudipta Pal, Ajay Kumar Chatterjee
Sep 29, 2004·Toxicology Letters·Aloísio Luiz BenedettiMarcio Alvarez-Silva
Mar 3, 2007·Biological & Pharmaceutical Bulletin·Yusuf YurumezMehmet Emin Buyukokuroglu
Nov 8, 2008·Expert Opinion on Biological Therapy·Seetal DoddMichael Berk
Jan 1, 2008·Environmental Toxicology and Pharmacology·Sinan Cağlar, Dürdane Kolankaya
Jul 1, 2009·Environmental Toxicology and Pharmacology·Fernando MañasNora Gorla
Nov 1, 2009·Environmental Toxicology and Pharmacology·Nahla S El-Shenawy
Aug 24, 2011·Journal of Medicinal Food·Kültiğin CavuşoğluEmine Yalçın
Sep 21, 2011·Bulletin of Environmental Contamination and Toxicology·Roberta CattaneoLuis Antonio de Avila
Apr 6, 2013·Veterinary Pathology·K N Gibson-CorleyD K Meyerholz
Mar 29, 2014·Interdisciplinary Toxicology·Anthony Samsel, Stephanie Seneff
Jul 24, 2014·Pesticide Biochemistry and Physiology·Magdalena ChłopeckaWojciech Karlik
Sep 24, 2014·Cardiovascular Toxicology·Steeve GressPaolo Emilio Puddu
Mar 25, 2015·The Lancet Oncology·Kathryn Z GuytonUNKNOWN International Agency for Research on Cancer Monograph Working Group, IARC, Lyon, France
Apr 18, 2015·Surgical Neurology International·Anthony Samsel, Stephanie Seneff
Oct 19, 2016·Environmental Toxicology·Gökhan EraslanSerap Şahin
May 1, 2015·General Physiology and Biophysics·Ines El-Bini DhouibSaloua El-Fazaa
Aug 19, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R MesnageG E Séralini
Oct 29, 2015·Fish Physiology and Biochemistry·Camila R MurussiVania L Loro
Jan 17, 2016·Environmental Toxicology and Pharmacology·Nicole M RoyJeremy Ochs
Aug 20, 2016·Environmental Science and Pollution Research International·Shahla Hosseini Bai, Steven M Ogbourne
Sep 2, 2016·Toxicology Mechanisms and Methods·Latifa HamdaouiTarek Rebai
Jul 25, 2018·Toxicology and Industrial Health·Mohaddeseh Mohammadi-SardooBagher Amirheidari

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Citations

Nov 17, 2019·Environmental Science and Pollution Research International·Latifa HamdaouiTarek Rebai
Feb 14, 2020·Environmental Health : a Global Access Science Source·Christopher J Portier
Mar 8, 2020·Environmental Science and Pollution Research International·Mohamed Ahmed FathiChunmei Li
Aug 14, 2020·The Science of the Total Environment·José Silonardo Pereira de OliveiraGuilherme Malafaia
Jun 26, 2021·Pharmacology & Therapeutics·Brandán PedreTobias P Dick
Sep 23, 2021·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Shaimaa M M SalehMohamed Ahmed Ibrahim Ahmed
Jan 7, 2022·Annual Review of Pharmacology and Toxicology·Xiaojing WangMaría-Aránzazu Martínez

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