Antioxidant and endothelium-stabilizing effects of simvaglyzin on rabbits with experimental hypercholesterolemia

Bulletin of Experimental Biology and Medicine
Y I RaginoG A Tolstikov

Abstract

Simvaglyzin, a complex compound of simvastatin and glycyrrhizic acid, administered to rabbits with experimental hypercholesterolemiain in doses equivalent to 66.6 and 40 microg/kg simvastatin exhibited antioxidant capacity (decreased the content of lipid peroxidation products in the blood by 27-41%) and endothelium-normalizing effect (decreased the level of von Willebrand factor and endothelin-1 by 26-58 and 21-29%, respectively, compared to 200 microg/kg simvastatin, p<0.05).

References

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Citations

Nov 30, 2013·Bulletin of Experimental Biology and Medicine·Z I Mikashinovich, E S Belousova
Dec 2, 2008·Bulletin of Experimental Biology and Medicine·Y I RaginoG A Tolstikov
Dec 21, 2019·Environmental Science and Pollution Research International·Olga Yu SelyutinaNikolay E Polyakov

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