Antioxidant and free radical-scavenging activity of the extracellular death factor in Escherichia coli

Peptides
Yanfeng GaoYuanming Qi

Abstract

The extracellular death factor (EDF) is a newly discovered linear pentapeptide with the sequence of H-Asn-Asn-Trp-Asn-Asn-OH (NNWNN). It could act as a quorum-sensing molecule and participate in the mazEF-mediated cell death in Escherichia coli. In the present study, we firstly studied the antioxidant and free radical-scavenging activities of EDF. EDF could scavenge hydroxyl radicals in vitro and protect protein, lipid and DNA from being damaged by hydroxyl radicals. Our results indicated that this extracellular death factor might have dual effects during the programmed cell death process of Escherichia coli.

References

Apr 18, 2001·Journal of Agricultural and Food Chemistry·E A DeckerB Frei
Mar 6, 2003·Journal of Bacteriology·Boaz SatHanna Engelberg-Kulka
Oct 18, 2005·Journal of Ethnopharmacology·Stephen S LeonardGabriel K Harris
Sep 7, 2007·Cell·Gerard D Wright
Sep 7, 2007·Cell·Michael A KohanskiJames J Collins
Oct 27, 2007·Science·Roberto Kolter
Dec 27, 2007·Journal of Medicinal Food·R Yazdanparast, A Ardestani
Mar 7, 2008·Microbiology and Molecular Biology Reviews : MMBR·Kelly C Rice, Kenneth W Bayles
Jun 13, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Arti R VermaChandana V Rao
Jul 31, 2009·Communicative & Integrative Biology·Hanna Engelberg-KulkaIlana Kolodkin-Gal
Dec 17, 2009·Molecular Cell·Bryan W DaviesGraham C Walker

❮ Previous
Next ❯

Citations

Jun 27, 2013·Critical Reviews in Microbiology·Bhaskar Chandra Mohan RamisettyRamachandran Sarojini Santhosh
Mar 5, 2013·Biochimica Et Biophysica Acta·Gregory M CookVickery L Arcus
May 20, 2017·World Journal of Gastroenterology : WJG·Lin LiYang Xu
May 6, 2015·Journal of Complementary & Integrative Medicine·Bruno Moukette MouketteJeanne Yonkeu Ngogang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.