Antioxidant and free radical scavenging properties of N-acetylcysteine amide (NACA) and comparison with N-acetylcysteine (NAC)

Free Radical Research
Burhan AtesNuran Ercal

Abstract

The antioxidant potential of N-acetylcysteine amide (NACA), also known as AD4, was assessed by employing different in vitro assays. These included reducing power, free radical scavenging capacities, peroxidation inhibiting activity through linoleic acid emulsion system and metal chelating capacity, as compared to NAC and three widely used antioxidants, alpha-tocopherol, ascorbic acid and butylated hydroxytoluene (BHT). Of the antioxidant properties that were investigated, NACA was shown to possess higher 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) radical scavenging ability and reducing power than NAC, at all the concentrations, whereas the scavenging ability of H(2)O(2) differed with concentration. While NACA had greater H(2)O(2) scavenging capacity at the highest concentration, NAC was better than NACA at lower concentrations. NAC and NACA had a 60% and 55% higher ability to prevent beta-carotene bleaching, respectively, as compared to control. The chelating activity of NACA was more than 50% that of the metal chelating capacity of EDTA and four and nine times that of BHT and alpha-tocopherol, respectively. When compared to NACA and NAC; alpha-tocopherol had higher DPPH scavenging abilities and BHT and alpha-tocopherol had ...Continue Reading

References

Feb 1, 1991·Clinical Pharmacokinetics·M R Holdiness
Feb 1, 1995·Free Radical Biology & Medicine·S J Stohs, D Bagchi
Jan 1, 1993·Journal of Cellular Biochemistry. Supplement·N De Vries, S De Flora
Jul 3, 2007·Current Opinion in Pharmacology·Kondala R AtkuriLeonore A Herzenberg

❮ Previous
Next ❯

Citations

May 14, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Kana ShimadaChiharu Kishimoto
Mar 12, 2013·Free Radical Research·K SunithaK S Girish
Nov 17, 2012·Metabolism: Clinical and Experimental·Amany K ElshorbagyCarmen E Perrone
Nov 26, 2015·Toxicology Letters·Ahdab KhayyatNuran Ercal
May 7, 2011·Obesity·Amany K ElshorbagyHelga Refsum
Nov 3, 2009·Biochemical and Biophysical Research Communications·Cana ParkDong Gun Lee
Jun 24, 2015·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Mattias GüntherMårten Risling
Oct 9, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Rohitas Deshmukh, Vishal Trivedi
Feb 15, 2015·Brain Research·Yasaswi MaddiralaNuran Ercal
Jul 18, 2012·The Journal of Organic Chemistry·A Stephen K HashmiFrank Rominger
Aug 26, 2014·Journal of Cardiovascular Pharmacology and Therapeutics·Kana ShimadaChiharu Kishimoto
Jan 19, 2011·Arquivos de neuro-psiquiatria·Nelson de Azambuja Pereira FilhoLigia Maria Barbosa Coutinho
May 11, 2018·Free Radical Research·Giancarlo AldiniFrancesco Sergio
Oct 29, 2018·Journal of Cellular Biochemistry·Fariheen Aisha AnsariRiaz Mahmood
Mar 26, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ivana CacciatoreAntonio Di Stefano
Feb 17, 2018·Clinical Oral Investigations·Jasmina MartacicMaria Glibetic
Aug 6, 2013·Pflügers Archiv : European journal of physiology·Abram KatzHåkan Westerblad
Oct 29, 2010·Medicine and Science in Sports and Exercise·Leonardo F FerreiraMichael B Reid
Sep 13, 2019·The Journal of Clinical Endocrinology and Metabolism·Chia-Hung ChouJehn-Hsiahn Yang
Nov 21, 2019·Mini Reviews in Medicinal Chemistry·Annalise R PfaffNuran Ercal
Aug 16, 2016·Biological Chemistry·Alessandra FraternaleMauro Magnani
Apr 20, 2019·Oxidative Medicine and Cellular Longevity·Huizhen Wang, Xin Zhang
Oct 16, 2019·Biointerphases·Sudipto DattaPallab Datta
Nov 27, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Carlos G ReisAngelo Piato
Jan 23, 2021·International Journal of Molecular Sciences·Marta GueriniPaola Perugini
Feb 23, 2021·Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents·Haizhou ZhuSwati S More
Feb 9, 2021·American Journal of Physiology. Endocrinology and Metabolism·Sarah J BlackwoodAbram Katz
Sep 22, 2009·The Journal of Physical Chemistry. B·Neha Agnihotri, P C Mishra
May 19, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mateja Manček-KeberRoman Jerala
May 16, 2021·Ecotoxicology and Environmental Safety·Xiaohong LiWanwei Li
Aug 28, 2021·Antioxidants·Maria Nunzia De LucaVittorio Unfer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Ilhami GulcinMehmet Emin Buyukokuroglu
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Sindhu Mathew, T Emilia Abraham
African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM
M Umamaheswari, T K Chatterjee
© 2022 Meta ULC. All rights reserved