Antioxidant and hepatoprotective effects of mixed micellar lipid formulation of phyllanthin and piperine in carbon tetrachloride-induced liver injury in rodents

Food & Function
Neeraj K SethiyaS H Mishra

Abstract

Phyllanthin, a sparingly water-soluble hepatoprotective lignin obtained from Phyllanthus amarus Schum. et Thonn. (Euphorbiaceae) possesses low bioavailability. Phyllanthin along with piperine (a nutraceutical bioenhancer) was formulated as a mixed micellar lipid formulation (MMLF) in the present study and investigated to resolve the low bioavailability and enhance hepatoprotective effects on oral administration. Hepatoprotective, antioxidant and bioavailability studies of MMLF, a complex phosphatidylcholine formulation of phyllanthin (CP-PC), phyllanthin + piperine (CP-P-PC) and its corresponding non-formulated phyllanthin have been carried out. Phyllanthin (30 mg kg(-1) p.o.), CP-PC (30 mg kg(-1) p.o.), CP-P-PC (30 mg kg(-1) p.o.) and the reference drug silymarin (100 mg kg(-1), p.o.) were administered daily to rats for 10 days, followed by liver damage by administering a 1 : 1 (v/v) mixture of CCl4 and olive oil (1 ml kg(-1), i.p.) for 7 days from day 4 to day 10. The degree of protection was evaluated by determining the level of marker enzymes (SGOT and SGPT), bilirubin (TB) and total proteins (TP). Further, the effects of MMLF on lipid peroxidation (LPO), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutat...Continue Reading

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Citations

Oct 22, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Menaga IlangkovanSyed Nasir Abbas Bukhari
Feb 7, 2017·Connective Tissue Research·Fengyan GongYan Wen
Sep 16, 2020·Phytotherapy Research : PTR·Iahtisham-Ul HaqMohammad S Mubarak
Feb 28, 2019·Critical Reviews in Analytical Chemistry·Christian Rafael Quijia, Marlus Chorilli
Jun 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Faiyaz ShakeelSultan Alshehri
Mar 17, 2021·Journal of Biochemical and Molecular Toxicology·Hui WangThamaraiselvan Rengarajan
Nov 6, 2020·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Christian Rafael QuijiaMarlus Chorilli
Aug 15, 2021·Bioorganic Chemistry·Zhi-Hao TianLiang Xiong

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