Antioxidant and in vitro anticancer activities of phenolics isolated from sugar beet molasses

BMC Complementary and Alternative Medicine
Mingshun ChenShujuan Yu

Abstract

In the present study, the phenolic compounds were prepared using ultrasonic-aid extraction from sugar beet molasses (SBM). Gallic acid (GA), cyanidin-3-O-glucoside chloride (CGC) and epicatechin (EP) were produced after column chromatography from the extraction, and further detected using NMR, QTOF-MS and ESI-MS/MS. The three compounds exhibited strong antioxidant activities including DPPH radical scavenging activities, ABTS radical scavenging activities and ORAC values. GA showed the strongest antioxidant activity. Antitumor activities significantly increased in a dose-dependent manner. In particular, the CGC had growth inhibitory activities of 94.86, 87.27 and 67.13% against the human colon (CACO-2), hepatocellular (HepG2) and breast (MCF-7) carcinoma cell lines, respectively, at the highest concentration of 400 μg/mL of the extracts. These results suggest that the three compounds are key chemical compositions valuable for preparing functional foods in the food industry. The results suggested that SBM is a natural source of antioxidant and antitumor agents for preparing functional foods.

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Citations

Jun 28, 2016·International Journal of Molecular Sciences·Mingshun ChenShujuan Yu
Nov 16, 2016·Antioxidants·Hans VergauwenChris van Ginneken
Dec 3, 2016·Nutrition Journal·Preethi G AnantharajuSubbaRao V Madhunapantula
May 26, 2020·Critical Reviews in Food Science and Nutrition·Sônia Paula Alexandrino de OliveiraEvandro Leite de Souza
Sep 26, 2020·International Journal of Molecular Sciences·Monika NaumowiczJoanna Kotyńska
Sep 25, 2017·Journal of Agricultural and Food Chemistry·Mingshun Chen, Shujuan Yu

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Methods Mentioned

BETA
ABTS

Software Mentioned

SPSS

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