Abstract
In the present study, the phenolic compounds were prepared using ultrasonic-aid extraction from sugar beet molasses (SBM). Gallic acid (GA), cyanidin-3-O-glucoside chloride (CGC) and epicatechin (EP) were produced after column chromatography from the extraction, and further detected using NMR, QTOF-MS and ESI-MS/MS. The three compounds exhibited strong antioxidant activities including DPPH radical scavenging activities, ABTS radical scavenging activities and ORAC values. GA showed the strongest antioxidant activity. Antitumor activities significantly increased in a dose-dependent manner. In particular, the CGC had growth inhibitory activities of 94.86, 87.27 and 67.13% against the human colon (CACO-2), hepatocellular (HepG2) and breast (MCF-7) carcinoma cell lines, respectively, at the highest concentration of 400 μg/mL of the extracts. These results suggest that the three compounds are key chemical compositions valuable for preparing functional foods in the food industry. The results suggested that SBM is a natural source of antioxidant and antitumor agents for preparing functional foods.
References
Nov 5, 1997·The Journal of Biological Chemistry·I WernerW Eisenreich
Jun 25, 1999·Free Radical Biology & Medicine·R ReC Rice-Evans
May 16, 2002·Journal of Agricultural and Food Chemistry·Boxin OuElizabeth K Deemer
May 10, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Z Sroka, W Cisowski
Sep 19, 2006·The International Journal of Biochemistry & Cell Biology·Marian ValkoJoshua Telser
Oct 31, 2008·Talanta·Iñaki BerregiJosé Ignacio Miranda
Sep 10, 2009·Journal of Agricultural and Food Chemistry·Jian-Ying Feng, Zai-Qun Liu
Nov 10, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shahriar Khadem, Robin J Marles
Jul 22, 2011·Food & Function·Li-Chen WuJa-An Annie Ho
Dec 23, 2011·International Journal of Cancer. Journal International Du Cancer·Hifzur Rahman SiddiqueMohammad Saleem
Oct 9, 2012·BMC Complementary and Alternative Medicine·Anjaneya S RavipatiBalaram Vysetti
Nov 30, 2012·Journal of Agricultural and Food Chemistry·Veronica ValliAlessandra Bordoni
Feb 21, 2013·Food & Function·Jelena J VulićVesna T Tumbas
Jan 15, 2014·Food & Function·Kamila FilipiakSonia de Pascual-Teresa
Jan 21, 2014·Food & Function·Vadavanath Prabhakaran VineethaKozhiparambil Gopalan Raghu
Feb 11, 2014·Carbohydrate Polymers·Ana FernandesVictor de Freitas
May 21, 2014·Oncology Letters·Bing Zhao, Mengcai Hu
May 28, 2014·Journal of Biochemical and Molecular Toxicology·Ke WangFanfan Zhou
Citations
Jun 28, 2016·International Journal of Molecular Sciences·Mingshun ChenShujuan Yu
Nov 16, 2016·Antioxidants·Hans VergauwenChris van Ginneken
Jul 25, 2019·BMC Complementary and Alternative Medicine·Tayyaba AfsarMuhammad Rashid Khan
Dec 3, 2016·Nutrition Journal·Preethi G AnantharajuSubbaRao V Madhunapantula
May 26, 2020·Critical Reviews in Food Science and Nutrition·Sônia Paula Alexandrino de OliveiraEvandro Leite de Souza
Sep 26, 2020·International Journal of Molecular Sciences·Monika NaumowiczJoanna Kotyńska
May 1, 2021·Plants·Željana FredotovićDanica Bajić
May 11, 2021·Journal of Food Science and Technology·Ertan Ermis, Merve Özkan
Sep 25, 2017·Journal of Agricultural and Food Chemistry·Mingshun Chen, Shujuan Yu