Antioxidant and Membrane Binding Properties of Serotonin Protect Lipids from Oxidation

Biophysical Journal
Slim AzouziPascal Amireault

Abstract

Serotonin (5-hydroxytryptamine, 5-HT) is a well-known neurotransmitter that is involved in a growing number of functions in peripheral tissues. Recent studies have shown nonpharmacological functions of 5-HT linked to its chemical properties. Indeed, it was reported that 5-HT may, on the one hand, bind lipid membranes and, on the other hand, protect red blood cells through a mechanism independent of its specific receptors. To better understand these underevaluated properties of 5-HT, we combined biochemical, biophysical, and molecular dynamics simulations approaches to characterize, at the molecular level, the antioxidant capacity of 5-HT and its interaction with lipid membranes. To do so, 5-HT was added to red blood cells and lipid membranes bearing different degrees of unsaturation. Our results demonstrate that 5-HT acts as a potent antioxidant and binds with a superior affinity to lipids with unsaturation on both alkyl chains. We show that 5-HT locates at the hydrophobic-hydrophilic interface, below the glycerol group. This interfacial location is stabilized by hydrogen bonds between the 5-HT hydroxyl group and lipid headgroups and allows 5-HT to intercept reactive oxygen species, preventing membrane oxidation. Experimental a...Continue Reading

Citations

Dec 29, 2019·Antioxidants·Sinemyiz AtalayElzbieta Skrzydlewska
Apr 16, 2020·Journal of Clinical Medicine·Klétigui Casimir DembéléJuan Manuel Chao de la Barca
Aug 26, 2020·PloS One·Gamal A M Abdu-AllahBarry R Pittendrigh
Oct 2, 2019·Archives of Toxicology·Chongshan DaiTony Velkov
Dec 18, 2020·Frontiers in Cell and Developmental Biology·Anna BochicchioRainer A Böckmann
Dec 19, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Keuna JeonRuby May A Sullan
Feb 11, 2019·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Padma Murthi, Cathy Vaillancourt
Sep 20, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Alaa E El-SisiNermine M Abdelsalam
Feb 8, 2020·Biophysical Journal·Brian P JoseyMathias Lösche
May 7, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jéssica Iara GallCristiani Folharini Bortolatto
May 26, 2020·Biochimica Et Biophysica Acta. Biomembranes·Morgan RobinsonZoya Leonenko
Jun 5, 2021·Critical Reviews in Food Science and Nutrition·Junjie LinChun Cui
Jul 10, 2021·Cannabis and Cannabinoid Research·Eulla Keimili Fernandes Ferreira CavalheiroGislaine Tezza Rezin
Sep 3, 2021·The Journal of Physiological Sciences : JPS·Joanna KrukEwa Duchnik
Dec 22, 2021·Photochemistry and Photobiology·Laura G RezendeMauricio S Baptista

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Langmuir : the ACS Journal of Surfaces and Colloids
Marcos Ariel VillarrealGuillermo G Montich
The Quarterly Journal of Medicine
D G Grahame-Smith
Nihon rinsho. Japanese journal of clinical medicine
Kiyofumi Saijoh, Hironobu Katsuyama
© 2022 Meta ULC. All rights reserved