PMID: 15228082Jul 2, 2004Paper

Antioxidant and oxidative stress changes in experimental cor pulmonale

Molecular and Cellular Biochemistry
F FarahmandPawan K Singal

Abstract

Although right heart failure (RHF) contributes to 20% of all cardiovascular complications, most of the information available on RHF in general is based on the experiences with left heart failure. This study on RHF investigates changes in antioxidants and oxidative stress which are suggested to play a role in the transition from hypertrophy to failure. RHF subsequent to pulmonary hypertension was produced in rats by a single injection of monocrotaline (MCT, 60 mg/kg, i.p.). Based on hemodynamic, clinical and histopathologic observations, the animals were grouped in three functional stages at 1-, 2- and 6-week post-injection periods. In the 1-week group, RV pressure overload and hypertrophy, and a mild increase in antioxidant enzymes was seen. In the 2-week group, compensated HF, a significant increase in antioxidant enzymes, an increase in septal (IVS) wall thickness and leftward displacement of IVS without change in LV free wall were seen. In the 6-week group, lung and liver congestion, RVF and dilation, a decrease in antioxidant enzyme activities, increase in lipid peroxidation and severe bulging of the IVS into the left ventricle were seen. These changes in the hemodynamic, biochemical and histopathologic characteristics sugg...Continue Reading

Citations

Apr 24, 2008·Clinical and Experimental Pharmacology & Physiology·Maristela P Souza-RabboAdriane Belló-Klein
Sep 27, 2008·Acta Pharmacologica Sinica·Hong-fang JinJun-bao Du
Dec 17, 2010·World Journal of Cardiology·Vincent G DemarcoKevin C Dellsperger
Sep 20, 2011·Clinical and Experimental Pharmacology & Physiology·Fabiano Leichsenring-SilvaAdriane Belló-Klein
Feb 2, 2013·Canadian Journal of Physiology and Pharmacology·Rafael ColomboAdriane Belló-Klein
Sep 29, 2017·Cardiovascular Research·Berend E WesterhofAnton Vonk Noordegraaf
Oct 3, 2018·American Journal of Respiratory Cell and Molecular Biology·Mario BoehmRalph T Schermuly
May 26, 2020·Archives of Physiology and Biochemistry·C U BeckerA Belló-Klein
May 15, 2007·Journal of Cardiovascular Pharmacology and Therapeutics·Marcus Kret, Rohit Arora
Nov 12, 2009·Journal of Cardiovascular Pharmacology·Ana R L LudkeAdriane Belló-Klein
Mar 13, 2014·Hypertension·Nima GhasemzadehArshed A Quyyumi
Jan 16, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Masahito KajiyaFumihiko Kajiya
Jul 28, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Vincent G DeMarcoKevin C Dellsperger
Jan 12, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Everaldo M RedoutWarner S Simonides
Mar 27, 2010·American Journal of Respiratory and Critical Care Medicine·Simon Tual-ChalotM Carmen Martinez
Sep 14, 2018·Journal of Cardiovascular Pharmacology·Cristina Campos-CarraroAdriane Belló-Klein
Mar 20, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Denise LacerdaAlex Sander da Rosa Araujo
Apr 13, 2010·Antioxidants & Redox Signaling·Neelam KhaperPawan K Singal
Apr 30, 2015·Journal of Cardiovascular Pharmacology·Rafael ColomboAdriane Belló-Klein
Jul 4, 2013·Human & Experimental Toxicology·E BalB Sirmagul
Aug 14, 2019·Journal of Biochemical and Molecular Toxicology·Nikola Hadzi-PetrushevMitko Mladenov
Jul 14, 2017·British Journal of Pharmacology·Denise Dos Santos LacerdaAlex Sander da Rosa Araujo
Nov 22, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Natia QipshidzeSuresh C Tyagi
Feb 3, 2016·Heart Failure Reviews·Mariëlle C van de VeerdonkNorbert F Voelkel
Feb 11, 2021·Annual Review of Physiology·Weiling XuSerpil C Erzurum
Dec 12, 2020·International Journal of Molecular Sciences·Christine HirschhäuserRainer Schulz
Nov 1, 2016·Journal of Cardiovascular Pharmacology·Cristina CamposAdriane Belló-Klein
Apr 21, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Giana Blume CorssacAdriane Belló-Klein
May 26, 2021·Journal of the American Heart Association·Christelle LteifJulio D Duarte
May 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bruna Gazzi de Lima-SeolinAdriane Belló-Klein

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