Abstract
Gastric ulcers are among the most common diseases affecting humans. This study aimed at investigating the gastroprotective effects of manuka honey against ethanol-induced gastric ulcers in rats. The mechanism by which honey exerts its antiulcer potential was elucidated. Four groups of rats were used: control, ethanol (ulcer), omeprazole, and manuka honey. Stomachs were examined macroscopically for hemorrhagic lesions in the glandular mucosa, histopathological changes, and glycoprotein detection. The effects of oxidative stress were investigated using the following indicators: gastric mucosal nitric oxide (NO), reduced glutathione (GSH), lipid peroxide (MDA, measured as malondialdehyde) glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase. Plasma tumour necrosis factor-α, interleukin-1β, and IL-6 were also measured. Manuka honey significantly decreased the ulcer index, completely protected the mucosa from lesions, and preserved gastric mucosal glycoprotein. It significantly increased gastric mucosal levels of NO, GSH, GPx, and SOD. Manuka honey also decreased gastric mucosal MDA and plasma TNF-α, IL-1β, and IL-6 concentrations. In conclusion, manuka honey likely exerted its antiulcer, effect by keeping enzymati...Continue Reading
References
Dec 18, 1992·Science·J S StamlerJ Loscalzo
Aug 10, 1987·Life Sciences·T MizuiM Doteuchi
Jan 1, 1985·Gastroenterology·D HollanderH Gergely
Jan 31, 1972·Biochemical and Biophysical Research Communications·M NishikimiK Yagi
Jan 1, 1967·The Journal of Pediatrics·L F Hill
Jan 1, 1984·Methods in Enzymology·H Aebi
Oct 9, 1981·Science·S SzaboP W Frankel
Jul 1, 1994·Gastroenterology·J L WallaceG Cirino
Sep 1, 1993·The American Journal of Physiology·J F BrownB J Whittle
Aug 25, 1993·Molecular and Cellular Biochemistry·D Das, R K Banerjee
May 1, 1997·Journal of Nurse-midwifery·M C Brucker, M A Faucher
Jul 4, 1998·Digestive Diseases and Sciences·A BozkurtI Alican
Mar 12, 1999·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·K GharzouliS Khennouf
May 16, 2000·Journal of Wound Care·P C Molan
Jul 5, 2001·European Journal of Pharmacology·R I BersimbaevI G Tzoy
May 9, 2002·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Fabiana G Gonzalez, Luiz C Di Stasi
Dec 18, 2002·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Kamel GharzouliSeddik Khennouf
Oct 31, 2003·Journal of Medicinal Food·Noori S Al-Waili
Feb 6, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Margaret M TarpeyMatthew B Grisham
Jun 22, 2005·World Journal of Gastroenterology : WJG·Sheng-Hsuan ChenShiann Pan
Nov 15, 2006·Digestive Diseases and Sciences·Pelin Arda-PirincciRefiye Yanardag
Nov 13, 2007·Journal of Food Science·L M Chepulis
Jan 24, 2008·Journal of Food Science·L Chepulis, N Starkey
May 1, 2008·Journal of Gastroenterology and Hepatology·Sang Woon ParkKi Baik Hahm
Mar 24, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kelly Samara de Lira MotaLeônia Maria Batista
Aug 29, 2009·Nature Reviews. Gastroenterology & Hepatology·Kenneth R DeVault, Nicholas J Talley
Dec 1, 2010·European Journal of Epidemiology·Pagona LagiouDimitrios Trichopoulos
Mar 31, 2011·International Journal of Biological Sciences·Omotayo Owomofoyon ErejuwaSunil Gurtu
Sep 1, 2001·Environmental Toxicology and Pharmacology·N H CnubbenP J van Bladeren
Mar 14, 2012·Journal of Agricultural and Food Chemistry·Yoji KatoHiroe Kikuzaki
Apr 11, 2012·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Tarek K MotawiYomna R Ahmed
Sep 6, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hasan A AlzahraniBalkees A Bakhotmah
Dec 20, 2012·PloS One·Maryam HajrezaieMahmood Ameen Abdulla
Mar 22, 2013·PloS One·Kamal A KetulyMahmood A Abdulla
Apr 25, 2013·Journal of Ethnopharmacology·Siddig Ibrahim AbdelwahabOnn Haji Hashim
May 2, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Heyam M A SidahmedMaizatulakmal Yahayu
Jul 23, 2013·Food Chemistry·Ching W ChanElizabeth Harry
Oct 8, 2013·Asian Pacific Journal of Tropical Biomedicine·Yong DuLixin Zhu
Nov 26, 2013·Clinics·Zakiah JubriGoon Jo Aan
Citations
Jan 18, 2017·Free Radical Research·Jannis KountourasGeorgia Deretzi
Mar 31, 2017·BMC Complementary and Alternative Medicine·Serene HilaryCarine Platat
Mar 3, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Saad B AlmasaudiSteve M Harakeh
Jan 8, 2017·American Journal of Clinical Dermatology·Sami K Saikaly, Amor Khachemoune
Feb 8, 2018·Acta Biochimica Et Biophysica Sinica·Qinchen LiZheng Liu
Dec 8, 2017·Oxidative Medicine and Cellular Longevity·Cynthia Layse Ferreira de AlmeidaTeresinha Gonçalves da Silva
May 5, 2017·Integrative Medicine Insights·M G MiguelM L Faleiro
Jun 15, 2018·Nutrients·Oscar Guzmán-GómezGermán Alberto Chamorro-Cevallos
Aug 7, 2018·Food & Function·Maria Luiza Rolim BezerraJailane de Souza Aquino
Oct 3, 2019·Journal of Food Biochemistry·Huseyin SahinSevgi Kolayli
Jan 16, 2020·Drug Development and Industrial Pharmacy·Mona BashaShereen H Noshi
Apr 6, 2020·Food & Function·Syam MohanSiddig Ibrahim Abdelwahab
Dec 4, 2019·Nutrition Research Reviews·Sadia AfrinMaurizio Battino
Jul 8, 2020·Antioxidants·Athanasios KarapetsasAglaia Pappa
Aug 5, 2020·Expert Opinion on Drug Discovery·Taraneh MousaviMohammad Abdollahi
Jan 18, 2020·The British Journal of Ophthalmology·Jacqueline TanFiona Stapleton
Aug 15, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Annuar FazaldaMohd Fahami Nur Azlina
Sep 19, 2019·Molecular Nutrition & Food Research·Haoan ZhaoWei Cao
Jul 25, 2019·Frontiers in Pharmacology·Xue ZhangCun Zhang
Apr 21, 2020·Oxidative Medicine and Cellular Longevity·Márcia Fernanda Correia Jardim PazAna Amélia de Carvalho Melo Cavalcante
Jul 18, 2020·Scientific Reports·Evans EffahAndrea Clavijo McCormick
Mar 9, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Soad K Al JaouniSteve Harakeh
Dec 13, 2019·Oxidative Medicine and Cellular Longevity·Lady D K T PrazeresAlmir G Wanderley
Feb 24, 2020·Cell Stress & Chaperones·Pan HuangCaifang Ren
Aug 5, 2020·Foods·Li-Ping SunKai Wang
Oct 28, 2018·International Journal of Environmental Research and Public Health·Nurul 'Izzah IbrahimAhmad Nazrun Shuid
Jan 26, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Maurizio BattinoTamara Forbes-Hernández
Nov 3, 2020·Molecular Biology Reports·Yasin DuranAhsen Yılmaz
Nov 5, 2020·Journal of Food Biochemistry·Susan F García FilleríaValeria A Tironi
Feb 20, 2021·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Khaled TaïbiKhalida Hadji
Mar 16, 2021·Frontiers in Pharmacology·Mohammad RaishFahad I Al-Jenoobi
Mar 25, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ming TianFuneng Geng
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuhan LiuHuihua Qu
Mar 31, 2021·Journal of Equine Veterinary Science·Anis AnisYasmin Sadek
May 1, 2021·Nutrients·Razan J MasadBasel K Al-Ramadi
Aug 10, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Luisa Ferreira CruzMarcelo Gonzaga de Freitas Araújo
Mar 23, 2021·Phytotherapy Research : PTR·Narges Navaei-AlipourMajid Ghayour-Mobarhan
Nov 26, 2021·Journal of Food Biochemistry·Adekemi Grace OluwafemiBukola Tola Aluko
Jan 4, 2022·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Naglaa M AmmarSherif Afifi