Antioxidant, Anti-Inflammatory and Cytotoxic Properties of Centaurea africana Lamk var. [Bonnet] M].

Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
Sabrina HadjiraSouad Ameddah

Abstract

In Algerian traditional medicine, Centaurea species are well known in traditherapy. Centaurea africana has been used in folk medicine for the treatment of several inflammatory disorders. This study aims to examine the antioxidant, anti-inflammatory and anti-proliferative potential of both n-Butanol (BECA) and ethyl acetate (EAECA) extracts of Centaurea africana. The phytochemical analysis of both BECA and EAECA were explored and the antioxidant activities were investigated by measuring the DPPH° scavenging effect, the reducing power and the inhibition of lipid peroxidation (LPO) induced by by Fe2+/ ascorbic acid system. The antiinflammatory properties were determined by measuring the NO° scavenging effect and by using carrageenan-induced rat paw oedema. The antiproliferative activity was studied on HT29 (human colorectal adenocarcinoma), OV2008 (human ovarian cancer) and C6 (Rattus norvegicus brain glioma) cell lines using the Sulforhodamine B assay. The total polyphenol contents (TPC) of EAECA and BECA are recorded at 125.24±10.14 and 53.03±2.50 mgGAE/g extract, respectively. Both extracts revealed the antioxidant activity in a concentration-dependent manner; this effect is more pronounced with EAECA. The BECA exhibited a high...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jul 4, 1990·Journal of the National Cancer Institute·P SkehanM R Boyd
Jun 1, 1971·Journal of Neurochemistry·S Bishayee, A S Balasubramanian
Mar 1, 1982·The Journal of Investigative Dermatology·P P BradleyG Rothstein
Jan 1, 1994·Methods in Enzymology·L MarcocciM Gardès-Albert
Dec 1, 1993·Journal of Ethnopharmacology·R E NegreteG Eckhardt
Feb 5, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J B Calixto
Apr 5, 2007·Nature Protocols·Vanicha Vichai, Kanyawim Kirtikara
Aug 26, 2009·Journal of Ethnopharmacology·Ufuk KocaEsra Küpeli Akkol
Feb 26, 2011·Journal of Pharmacology & Pharmacotherapeutics·Carol KilkennyDouglas G Altman
Jun 30, 2011·Pharmacognosy Research·Manjit SinghAjudhia Nath Kalia
Feb 5, 2013·Journal of Advanced Pharmaceutical Technology & Research·Ciddi Veeresham
Aug 1, 2013·Indian Journal of Pharmaceutical Sciences·Shruti SrivastavaR L Khosa
Jan 11, 2014·Pharmaceutical Biology·Sura Baykan ErelCanan Karaalp
Nov 5, 2016·Combinatorial Chemistry & High Throughput Screening·Djihane AzzouziRatiba Mekkiou
May 10, 2017·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Riham Omar BakrNahla Ayoub
Feb 23, 2018·Oncotarget·Linlin ChenLing Zhao
Apr 28, 2018·Circulation Research·Steven J ForresterKathy K Griendling
Aug 4, 2018·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Jazia SdayriaMohamed Salah Allagui
Sep 25, 2018·Frontiers in Pharmacology·Ali AttiqWaqas Ahmad

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