Antioxidant, anti-inflammatory and anticarcinogenic activities of edible red oak (Quercus spp.) infusions in rat colon carcinogenesis induced by 1,2-dimethylhydrazine

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Martha Rocío Moreno-JimenezMinerva Ramos-Gomez

Abstract

Red oak (Quercus spp.) leaves are traditionally used as food in Mexico, and some of their infusions have potential anticarcinogenic and anti-inflammatory effects; however, these properties have not yet been scientifically tested. The aim of this work was to explore the anti-inflammatory activity in HT-29 cells and anticarcinogenic effect in 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis of red oak infusions. Quercus infusions were prepared and administered as the sole source of drink to male Sprague-Dawley rats (1% w/v) for the entire 26-week experimental period. On week 4, rats received 8 subcutaneous injections of DMH (21 mg/kg body weight) once a week. The results showed that mean tumor (0.9 ± 0.2 vs. 2.6 ± 0.3) and multiplicity (1.2 ± 0.1 vs. 2.0 ± 0.23), and β-catenin protein level (2.2-fold) in adenocarcinomas were significantly lower in Quercus  sideroxyla-treated group compared with DMH group. By contrast, Quercus  durifolia and Quercus  eduardii infusions had no protective effect. Additionally, the experiments in HT-29 cells confirmed that Q. sideroxyla infusion effectively decreased the levels of the inflammatory markers COX-2 and IL-8 by modulating the expression of NF-κB. These results highlight some of th...Continue Reading

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Citations

Aug 18, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Mehdi TaibBadiaa Lyoussi
Nov 22, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Marcela Soto-GarcíaNorma Paniagua-Castro
May 2, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Peipei YinYujun Liu
Nov 1, 2016·Comprehensive Reviews in Food Science and Food Safety·Ana F VinhaM Beatriz P P Oliveira
Jan 29, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Mahvash Alizade NainiAida Iraji

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