Antioxidant, antiapoptotic, antigenotoxic, and hepatic ameliorative effects of L-carnitine and selenium on cadmium-induced hepatotoxicity and alterations in liver cell structure in male mice

Ecotoxicology and Environmental Safety
Helal S H Abu-El-ZahabWed A Al-Harthi

Abstract

L-carnitine (LC) and selenium (Se) have significant protective and antioxidant effects on several tissues. Cadmium (Cd), widely used in some industries and emitted from fossil fuels, is a heavy metal having a number of side effects, including hepatotoxicity. This study aims to assess the ameliorative function of both LC and SeCl4 on cadmium chloride (CdCl2)-induced liver toxicity. In total, 70 male mice included in this study were allocated to seven groups: control, CdCl2, LC, SeCl4, CdCl2 plus SeCl4, CdCl2 plus LC, CdCl2 plus SeCl4 and LC groups. Hepatic aminotransferase (aspartate aminotransferase [AST] and alanine transaminase [ALT]) activity and tumor necrosis factor-alpha [TNF-α] levels, as well as the antioxidant biomarkers (superoxide dismutase [SOD], glutathione reductase [GRx], glutathione-S-transferase [GST] and catalase [CAT], were examined. Histological and transmission electron microscopic [TEM] variations in the liver were used as indicators of liver damage after the administration of CdCl2-alone or CdCl2 with LC, SeCl4, or both. Genotoxic effects of CdCl2 were also evaluated and the possible roles of SeCl4 and/or LC on the expression of the antioxidant enzymes were studied. Results showed that administration of L...Continue Reading

Citations

Nov 7, 2019·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Cyrus JaliliAli Ghanbari
Dec 22, 2019·Biological Trace Element Research·Wed A AlharthiHanan Saleh
Oct 11, 2020·Life Sciences·Gülname Fındık GüvendiYasemen Adalı
Jan 15, 2021·The Science of the Total Environment·Mohammad NaderiRaymond W M Kwong
Jan 15, 2021·Ecotoxicology and Environmental Safety·Huan WangHoujuan Xing
Feb 18, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Cibele F TeixeiraVerônica F Azzolin
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lenka SochorovaJiri Sochor
Aug 24, 2021·Journal of Toxicology·Suryakant NitureDeepak Kumar
Nov 26, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Lamiaa A KhatabAsser I Ghoneim

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