Antioxidant, antihyperglycemic, and antidyslipidemic effects of Brazilian-native fruit extracts in an animal model of insulin resistance

Redox Report : Communications in Free Radical Research
Juliane de Souza CardosoFrancieli Moro Stefanello

Abstract

Insulin resistance (IR) plays an important role in the development of many diseases, such as diabetes mellitus. Therefore, the aim of the present study was to evaluate the effects of the extracts from fruits native to Brazil on metabolic parameters and hepatic oxidative markers in an animal model of insulin resistance induced by dexamethasone (DEX). Wistar rats received water or extracts of Eugenia uniflora or Psidium cattleianum, once a day for 21 days. For the last 5 days, the rats received an intraperitoneal injection of saline or DEX. DEX caused a reduction in body weight gain and relative pancreatic weight, as well as glucose intolerance, and an increase in serum glucose and triacylglycerol levels. The extracts were found to prevent hyperglycemia and hypertriglyceridemia. DEX caused an increase in the levels of thiobarbituric acid-reactive substances and reactive oxygen species production in the liver of rats, and both extracts prevented these changes. In addition, hepatic glutathione peroxidase activity was reduced by DEX. However, total thiol content and activities of catalase, superoxide dismutase, and delta-aminolevulinate dehydratase were not altered in any of the tested groups. Fruit extracts of E. uniflora and P. ca...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jan 1, 1984·Methods in Enzymology·H Aebi
Aug 28, 2004·Diabetes·Emilie GesinaBernadette Breant
Jul 22, 2008·Metabolism: Clinical and Experimental·Naoto Matsuzawa-NagataShuichi Kaneko
Feb 7, 2009·Diabetes & Metabolism·J Capeau
Apr 6, 2011·Diabetologia·J C Henquin, J Rahier
Mar 4, 2014·BioMed Research International·Anu RahalKuldeep Dhama
Apr 9, 2014·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·T J DionísioS L Amaral
Sep 5, 2014·International Journal of Experimental Pathology·Bruna B BighettiAlex Rafacho
Dec 2, 2014·International Journal of Molecular Medicine·Jong Seok LeeEock Kee Hong
Dec 26, 2015·Nutrition & Metabolism·Ramachandran Vinayagam, Baojun Xu
Feb 13, 2016·Brazilian Journal of Biology = Revista Brasleira De Biologia·M C ScurL G Temponi
May 5, 2016·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J YuZ P Zhou
Jun 18, 2016·Current Cardiology Reports·Audrey E Brown, Mark Walker
Feb 9, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Pathise Souto OliveiraFrancieli Moro Stefanello

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Citations

Jun 11, 2020·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Vanessa Plasse RamosRejane Giacomelli Tavares
Dec 18, 2018·3 Biotech· Bindu Jacob, Narendhirakannan R T
Aug 28, 2020·Periodontology 2000·Isabelle Laleman, Wim Teughels
Sep 16, 2018·Plant Foods for Human Nutrition·Fabiana Della BettaAna Carolina Oliveira Costa
Jan 10, 2021·Molecular and Cellular Endocrinology·Juliane de Souza CardosoRejane Giacomelli Tavares
Mar 29, 2021·Food Research International·Nayara Macêdo Peixoto AraujoGlaucia Maria Pastore
Apr 8, 2021·Phytotherapy Research : PTR·Betina M BeltrameAmélia T Henriques
Sep 29, 2019·Molecular and Cellular Endocrinology·Jucimara BaldissarelliMaria R Chitolina Schetinger
Oct 6, 2021·Chemistry & Biodiversity·Suzana C SantosPedro H Ferri

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