Antioxidant, antiradical, and anticholinergic properties of cynarin purified from the Illyrian thistle (Onopordum illyricum L.)

Journal of Enzyme Inhibition and Medicinal Chemistry
Meryem TopalSaleh H Alwasel

Abstract

Cynarin is a derivative of hydroxycinnamic acid and it has biologically active functional groups constituent of some plants and food. We elucidated the antioxidant activity of cynarin by using different in vitro condition bioanalytical antioxidant assays like DMPD(•+), ABTS(•+), O2(•-), DPPH(•) and H2O2 scavenging effects, the total antioxidant influence, reducing capabilities, Fe(2+) chelating and anticholinergic activities. Cynarin demonstrated 87.72% inhibition of linoleic acid lipid peroxidation at 30 µg/mL concentration. Conversely, some standard antioxidants like trolox, α-tocopherol, butylated hydroxytoluene (BHT), and butylated hydroxyanisole (BHA) exhibited inhibitions of 90.32, 75.26, 97.61, 87.30%, and opponent peroxidation of linoleic acid emulsion at the identical concentration, seriatim. Also, cynarin exhibited effective DMPD(•+), ABTS(•+), O2(•-), DPPH(•), and H2O2 scavenging effects, reducing capabilities and Fe(2+) chelating effects. On the contrary, IC50 and K(i) parameters of cynarin for acetylcholinesterase enzyme inhibition were determined as 243.67 nM (r(2): 0.9444) and 39.34 ± 13.88 nM, respectively. This study clearly showed that cynarin had marked antioxidant, anticholinergic, reducing ability, radical-...Continue Reading

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Citations

Mar 18, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Süleyman YılmazClaudiu T Supuran
Apr 8, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Cebrail Gürsulİlhami Gülçin
Apr 15, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Burhanettin TuranClaudiu T Supuran
Jun 1, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Fadime ÖzbeyClaudiu T Supuran
Jun 17, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Fazile Nur Ekinci AkdemirRecep Soslu
Jul 9, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Sybil ObuobiPeter Mátyus
Aug 25, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Fazile Nur Ekinci AkdemirSaleh H Alwasel
Sep 7, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Daniela De VitaLuigi Scipione
Jan 20, 2017·Journal of Enzyme Inhibition and Medicinal Chemistry·Parham TaslimiSabir Mamedov
Nov 15, 2017·Archiv der Pharmazie·Umit M KocyigitMustafa Ceylan
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Apr 7, 2020·Journal of Enzyme Inhibition and Medicinal Chemistry·Mustafa DurgunClaudiu T Supuran
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