Antioxidant Approach as a Cardioprotective Strategy in Chemotherapy-Induced Cardiotoxicity.

Antioxidants & Redox Signaling
Christian Cadeddu DessalviGiuseppe Mercuro

Abstract

Significance: Chemotherapy-induced cardiotoxicity (CTX) has been associated with redox signaling imbalance. In fact, redox reactions are crucial for normal heart physiology, whereas excessive oxidative stress can cause cardiomyocyte structural damage. Recent Advances: An antioxidant approach as a cardioprotective strategy in this setting has shown encouraging results in preventing anticancer drug-induced CTX. Critical Issues: In fact, traditional heart failure drugs as well as many other compounds and nonpharmacological strategies, with a partial effect in reducing oxidative stress, have been shown to counterbalance chemotherapy-induced CTX in this setting to some extent. Future Directions: Given the various pathways of toxicity involved in different chemotherapeutic schemes, interactions with redox balance need to be fine-tuned and a personalized cardioprotective approach seems to be required.

References

Jun 16, 1997·Toxicology Letters·Y SadzukaS Hirota
Jun 17, 2000·The American Journal of Medicine·J M McCord
May 2, 2002·Nature Medicine·Steven A CroneKuo-Fee Lee
Jun 19, 2002·Circulation·Kazufumi NakamuraTohru Ohe
Jun 22, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B V JensenS L Nielsen
Oct 3, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Haruhiro TokoIssei Komuro
Dec 25, 2002·Toxicology and Applied Pharmacology·D L SantosK B Wallace
May 29, 2003·British Journal of Cancer·G CianciC Ficorella
Oct 18, 2003·Journal of Cancer Research and Clinical Oncology·S M Swain, P Vici
Jan 22, 2004·Cardiovascular Toxicology·Robert J BoucekJames Atkinson
Sep 24, 2004·Journal of Molecular and Cellular Cardiology·Paolo SpallarossaClaudio Brunelli
Sep 25, 2004·Mass Spectrometry Reviews·Isabella Dalle-DonneAldo Milzani
Feb 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kathy D MillerHope S Rugo
Mar 15, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Malgorzata Tokarska-SchlattnerUwe Schlattner
Apr 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael S Ewer, Scott M Lippman
Dec 6, 2005·International Journal of Cardiology·Mayako SogaYoshifusa Aizawa
Dec 13, 2006·Journal of the American College of Cardiology·Nihat KalayAli Ergin
Feb 20, 2007·Cancer Research·Kathleen GabrielsonNicole Muratore
Aug 28, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M A de KorteP J Perik
Oct 12, 2007·The Journal of Pharmacology and Experimental Therapeutics·Kyoung-Han KimPeter H Backx
Dec 18, 2007·Lancet·Tammy F ChuMing Hui Chen
Jan 16, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Filomena de NigrisClaudio Napoli
Apr 2, 2008·Chemical Research in Toxicology·Pierantonio MennaGiorgio Minotti
Apr 26, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M L TelliS Srinivas
Sep 26, 2008·Integrative Cancer Therapies·Karen Y WondersReid Hayward
Sep 30, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Sharad RastogiHani N Sabbah
Oct 22, 2008·Oncogene·D N Dhanasekaran, E P Reddy
Dec 9, 2008·The Biochemical Journal·Michael P Murphy
Feb 26, 2009·Advances in Experimental Medicine and Biology·Takashi ItoJunichi Azuma
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Glenwood D GossLesley Seymour

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Methods Mentioned

BETA
carbonylation
electron microscopy
acetylation

Related Concepts

Related Feeds

Cardiotoxicity

Cardiotoxicity refers to the muscle damage or dysfunction of heart electrophysiology caused by drug intake or due to disease complications. It is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. Here is the latest research.

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