Antioxidant Approaches to Management of Ionizing Irradiation Injury

Antioxidants
Joel GreenbergerMichael W Epperly

Abstract

Ionizing irradiation induces acute and chronic injury to tissues and organs. Applications of antioxidant therapies for the management of ionizing irradiation injury fall into three categories: (1) radiation counter measures against total or partial body irradiation; (2) normal tissue protection against acute organ specific ionizing irradiation injury; and (3) prevention of chronic/late radiation tissue and organ injury. The development of antioxidant therapies to ameliorate ionizing irradiation injury began with initial studies on gene therapy using Manganese Superoxide Dismutase (MnSOD) transgene approaches and evolved into applications of small molecule radiation protectors and mitigators. The understanding of the multiple steps in ionizing radiation-induced cellular, tissue, and organ injury, as well as total body effects is required to optimize the use of antioxidant therapies, and to sequence such approaches with targeted therapies for the multiple steps in the irradiation damage response.

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Citations

Oct 1, 2016·Journal of Clinical Anesthesia·Dilek KutanisHanife Kara
Aug 25, 2017·Antioxidants & Redox Signaling·Yulia Y TyurinaValerian E Kagan
Dec 24, 2019·Nanomedicine·Agnieszka Małgorzata PudlarzJanusz Szemraj
Jun 2, 2017·International Journal of Cancer. Journal International Du Cancer·Jianmin HuYa Cao
Jul 4, 2018·Journal of Biological Physics·Huseyin Ozan TekinMuhsin Konuk
Jul 11, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Krishna N MishraGhazi A Alsbeih

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