Antioxidant capacity of lenses with age-related cataract.

Oxidative Medicine and Cellular Longevity
Bojana KisicIlija Dragojevic

Abstract

The immediate cause of the occurrence of cataract is unknown, but oxidative damage and effects of reactive oxygen species are considered important in its etiopathogenesis. Our research was aimed at testing the nonenzyme antioxidant power of corticonuclear lens blocks, with different types and different maturity of age-related cataract. Clinical and biochemical researches were carried out in 101 patients with age-related cataract. In corticonuclear lens blocks of the patient, the concentration of nonprotein and total-SH groups and the concentration of total vitamin C and dehydroascorbic acid (DHA) were determined; the current redox balance of dehydroascorbate/ascorbate and total antioxidant power measured by ferric-reducing ability were examined. In corticonuclear lens blocks with incipient cataract a significantly higher concentration of GSH, total SH groups, concentration of total vitamin C and ascorbic acid (AA), and ferric-reducing ability were measured. The measured concentration of DHA is higher than the concentration of AA in the lenses with the incipient and mature cataract. The concentration ratio of redox couple DHA/AA is higher in lenses with mature cataract, where the measured concentration of AA was lower than in th...Continue Reading

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Citations

Oct 23, 2012·Biological Trace Element Research·Rasiah Pratheepa KumariKumarasamy Anbarasu
Apr 30, 2015·Oxidative Medicine and Cellular Longevity·Bosch-Morell FranciscoNavea Amparo
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Methods Mentioned

BETA
Assay
light scattering

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