PMID: 11605989Oct 19, 2001Paper

Antioxidant changes in the hypertrophied heart due to energy metabolic disorder

Basic Research in Cardiology
H KamiyaT Hayakawa

Abstract

Oxidative stress has been implicated in the pathogenesis of both heart hypertrophy and heart failure. Hypertrophied heart, in response to pressure overload, is associated with an increase in antioxidant capacity and a decrease in oxidative stress. However, in the hypertrophied heart due to energy metabolic disorder, antioxidant capacity has not been investigated. Antioxidant changes in juvenile visceral steatosis (JVS) mice, a model of heart hypertrophy due to disorder of fatty-acid oxidation, were examined at 4 weeks (developing hypertrophy stage) and 8 weeks of age (established hypertrophy stage). Superoxide dismutase activity in the JVS mice was higher than that in control mice at 4 weeks of age and was not different from that in the control mice at 8 weeks of age. Glutathione peroxidase activity in the JVS mice at 8 weeks of age was lower than that in the control mice. Catalase activity showed no significant differences between the control and the JVS mice. Lipid peroxidation in the JVS mice was significantly reduced at 4 weeks of age and increased toward control levels at 8 weeks of age. The levels of vitamin E in the heart were increased in the JVS mice at 8 weeks of age. To determine whether antioxidants affect the patho...Continue Reading

Citations

Sep 30, 2006·Journal of Biochemical and Molecular Toxicology·Zipporah T KamurenJohn B Watkins
Jul 24, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Mohamed BenderdourChristine Des Rosiers
Aug 2, 2003·European Journal of Haematology·Vip ViprakasitAlison May

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