Antioxidant defenses in the preterm lung: role for hypoxia-inducible factors in BPD?

Toxicology and Applied Pharmacology
Tiina M Asikainen, Carl W White

Abstract

Pulmonary antioxidants and their therapeutic implications have been extensively studied during past decades. The purpose of this review is to briefly summarize the key findings of these studies as well as to elaborate on some novel approaches with respect to potential preventive treatments for neonatal chronic lung disease bronchopulmonary dysplasia (BPD). Such new ideas include, for example, modification of transcription factors governing the hypoxic response pathways, important in angiogenesis, cell survival, and glycolytic responses. The fundamental strategy behind that approach is that fetal lung normally develops under hypoxic conditions and that this hypoxic, growth-favoring environment is interrupted by a premature birth. Importantly, during fetal lung development, alveolar development appears to be dependent on vascular development. Therefore, enhancement of signaling factors that occur during hypoxic fetal life ('continued fetal life ex utero'), including angiogenic responses, could potentially lead to improved lung growth and thereby alleviate the alveolar and vascular hypoplasia characteristic of BPD.

References

Nov 1, 1978·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·L FrankR J Roberts
Jan 1, 1992·Critical Reviews in Food Science and Nutrition·F Shahidi, P K Wanasundara
Oct 1, 1992·The American Journal of Physiology·L B Clerch, D Massaro
Apr 1, 1992·The American Review of Respiratory Disease·J J CoalsonR A Delemos
Jan 1, 1991·Free Radical Biology & Medicine·L Frank
Sep 30, 1991·The American Journal of Medicine·H Sies
Dec 1, 1991·American Journal of Respiratory Cell and Molecular Biology·Z MarchoM F Tsan
Feb 11, 1991·The American Review of Respiratory Disease·L R MargrafB B Dahms
Jan 1, 1991·Experimental Lung Research·F J WaltherH J Forman
Mar 1, 1990·Journal of Applied Physiology·M F TsanC Y Lee
Aug 1, 1990·American Journal of Diseases of Children·R A deLemosD R Gerstmann
Sep 15, 1987·The Biochemical Journal·M A Hass, D Massaro
Jan 1, 1988·Experimental Lung Research·S MatalonR H Notter
Feb 17, 1988·Biochimica Et Biophysica Acta·R C StrangeR Hume
Jan 1, 1986·Annual Review of Physiology·J D Crapo
Jun 1, 1987·Journal of Applied Physiology·B A HolmS Matalon
Oct 1, 1986·Biochimica Et Biophysica Acta·A A FryerR C Strange
Feb 16, 1967·The New England Journal of Medicine·W H NorthwayD Y Porter
Jul 1, 1982·Archives of Biochemistry and Biophysics·B A FreemanJ D Crapo
Jan 1, 1984·Annual Review of Physiology·P H Burri
Jan 1, 1982·Annals of the New York Academy of Sciences·R A EhrenkranzJ B Warshaw
Jan 1, 1981·The Journal of Pediatrics·L S Inselman, R B Mellins
Sep 1, 1982·Archives of Biochemistry and Biophysics·J F TurrensJ D Crapo
Oct 1, 1995·American Journal of Respiratory Cell and Molecular Biology·P PietarinenV L Kinnula
Jul 17, 1995·Biochemical and Biophysical Research Communications·G L WangG L Semenza
Sep 1, 1993·Pediatric Research·C V SmithS J Elliott
Sep 1, 1993·The Journal of Clinical Investigation·H FazzoneL B Clerch
Feb 1, 1993·The Journal of Clinical Investigation·L B Clerch, D Massaro
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·R M LebovitzM M Matzuk
Jan 1, 1996·Journal of the American Optometric Association·E Cheraskin

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Citations

Dec 4, 2013·Antioxidants & Redox Signaling·Sara K Berkelhamer, Kathryn N Farrow
Dec 18, 2013·Antioxidants & Redox Signaling·Trent E Tipple
May 26, 2007·The British Journal of Nutrition·Lucile BottFrédéric Gottrand
Nov 28, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Rubin M TuderIwona Fijalkowska
Jan 23, 2013·Toxicology and Applied Pharmacology·Binoy ShivannaBhagavatula Moorthy
Jul 31, 2012·Free Radical Biology & Medicine·Rønnaug SolbergGiuseppe Buonocore
Jul 14, 2010·European Journal of Pharmacology·Marwan EmaraPo-Yin Cheung
Mar 19, 2013·Free Radical Biology & Medicine·Sara K BerkelhamerPaul T Schumacker
Nov 28, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Daniele TrevisanutoUNKNOWN Neonatal Resuscitation Study Group, Italian Society of Neonatology
Sep 13, 2011·Free Radical Biology & Medicine·Binoy ShivannaBhagavatula Moorthy
Aug 29, 2016·Journal of Translational Medicine·Jute RichterJan Deprest
Apr 19, 2016·American Journal of Respiratory Cell and Molecular Biology·Qian LiTrent E Tipple
Aug 28, 2007·Archives of Biochemistry and Biophysics·Marwan EmaraPo-Yin Cheung
Aug 30, 2007·Pediatric Pulmonology·Géza BokodiBarna Vásárhelyi
Dec 1, 2007·Journal of Pediatric Gastroenterology and Nutrition·Serafina PerroneGiuseppe Buonocore
Oct 16, 2009·Pediatric Pulmonology·Carlo DaniFirmino F Rubaltelli
Apr 25, 2009·Pediatric Research·Richard L Auten, Jonathan M Davis
Jun 21, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ankur DattaSara K Berkelhamer
Dec 19, 2017·The Journal of Allergy and Clinical Immunology·In Su CheonJie Sun

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