Antioxidant effect of thiamine on acutely alcoholized rats and lack of efficacy using thiamine or glucose to reduce blood alcohol content

Basic & Clinical Pharmacology & Toxicology
Guilherme V PortariAlceu A Jordao

Abstract

Although there is no consensus about the use of glucose and thiamine for the treatment of acute ethanol intoxication, this is a routine practice in many countries. Our objective was to determine the efficacy of this treatment and the changes it causes in the antioxidant status of the liver. Male Wistar rats were intoxicated with an ethanol dose of 5 g/kg and divided into three groups: ethanol (EtOH; untreated), EtOH+G (treated with glucose), and EtOH+B1 (treated with thiamine). Blood and urinary ethanol as well as hepatic malondialdehyde, reduced glutathione and vitamin E were determined in all animals. Blood alcohol levels did not differ between groups, although urinary excretion was about four times higher in the group treated with thiamine (EtOH+B1). The malondialdehyde, reduced glutathione and vitamin E values used here as parameters of the antioxidant system of the liver showed improvement for the thiamine-treated group (EtOH+B1). Treatment with glucose or thiamine was ineffective in reducing blood alcohol levels in rats with acute ethanol intoxication. However, the beneficial effect of thiamine as an antioxidant for ethanol metabolism was demonstrated. Further investigations are necessary to clarify the urinary excretion ...Continue Reading

References

Jan 1, 1978·Methods in Enzymology·J A Buege, S D Aust
Jan 22, 1998·Free Radical Biology & Medicine·D A StoyanovskyA I Cederbaum
Mar 20, 2002·Current Molecular Medicine·C K Singleton, P R Martin
Mar 1, 2003·Journal of Toxicology and Environmental Health. Part a·D W ChoiY C Kim
Jul 8, 2003·Science of Aging Knowledge Environment : SAGE KE·Mark E Obrenovich, Vincent M Monnier
Feb 12, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Alceu Afonso JordãoHelio Vannucchi
Aug 12, 2004·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Nicholas S AberleJun Ren
Apr 12, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Pintu D Masalkar, Subodhini A Abhang
Jul 23, 2005·Annals of the New York Academy of Sciences·Toshihiko Osawa, Yoji Kato
Jul 23, 2005·Annals of the New York Academy of Sciences·Nikolaos KarachaliasPaul J Thornalley
Aug 10, 2005·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Björn LisanderAlan W Jones

❮ Previous
Next ❯

Citations

Sep 12, 2013·PloS One·Veedamali S SubramanianHamid M Said
Feb 2, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Guilherme Vannucchi PortariAlceu Afonso Jordao
Oct 4, 2015·Basic & Clinical Pharmacology & Toxicology·Hilal Bektas UysalBuket Demirci
Jan 1, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Khanh vinh quốc L Ng, Lan Thi Hoàng Nguyễn
Mar 29, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Padmanabhan SrinivasanHamid M Said
Aug 31, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hamid M Said
Nov 17, 2019·Antioxidants·Justyna PiechockaAnna Jędrusek-Golińska
Feb 15, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Padmanabhan SrinivasanHamid M Said
May 26, 2018·Journal of Aquatic Animal Health·David W WelchDale C Honeyfield
Jul 22, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Subrata SabuiHamid M Said
Nov 5, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kasin Yadunandam AnandamHamid M Said
Apr 4, 2021·Foods·Krystyna Szymandera-BuszkaAnna Jędrusek-Golińska

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.