Antioxidant Effects and Mechanisms of Medicinal Plants and Their Bioactive Compounds for the Prevention and Treatment of Type 2 Diabetes: An Updated Review

Oxidative Medicine and Cellular Longevity
Jeremiah Oshiomame Unuofin, Sogolo Lucky Lebelo

Abstract

Diabetes mellitus is a metabolic disorder that majorly affects the endocrine gland, and it is symbolized by hyperglycemia and glucose intolerance owing to deficient insulin secretory responses and beta cell dysfunction. This ailment affects as many as 451 million people worldwide, and it is also one of the leading causes of death. In spite of the immense advances made in the development of orthodox antidiabetic drugs, these drugs are often considered not successful for the management and treatment of T2DM due to the myriad side effects associated with them. Thus, the exploration of medicinal herbs and natural products as therapeutic sources for the treatment of T2DM is promoted because they have little or no side effects. Bioactive molecules isolated from natural sources have been proven to lower blood glucose levels via regulating one or more of the following mechanisms: improvement of beta cell function, insulin resistance, glucose (re)absorption, and glucagon-like peptide-1 homeostasis. In recent times, the mechanisms of action of different bioactive molecules with antidiabetic properties and phytochemistry are gaining a lot of attention in the area of drug discovery. This review article presents an update of the findings fr...Continue Reading

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Citations

Oct 22, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Gedefaw Getnet AmareYaschilal Muche Belayneh
Jun 3, 2021·Antioxidants·Proshanta RoySeyed Khosrow Tayebati
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mayadah Bashir ShehadehAla' Mustafa Abu-Odeh
Aug 27, 2021·Advances in Pharmacological and Pharmaceutical Sciences·Janette A LindstromJean Sparks
Sep 11, 2021·Journal of Complementary & Integrative Medicine·Saeed NiazmandMahdiyeh Hedayati-Moghadam

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Methods Mentioned

BETA
Glycation
MDA

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