Antioxidant effects of alpha tocopherol, ascorbic acid and L-methionine on lead induced oxidative stress to the liver, kidney and brain in rats

Toxicology
R C PatraS K Dwivedi

Abstract

Lead exposure related oxidative stress has been incriminated, at least in part, to its toxic effects in different organs. The present investigation was carried out to study the ameliorative effects of antioxidant (ascorbic acid, alpha tocopherol or L-methionine) alone and antioxidant (alpha tocopherol) plus a conventional chelator (CaNa2 EDTA) on some of the parameters indicative of oxidative stress in the liver, kidney and brain in lead-exposed rats. Rats were given 0 (n=6, healthy controls) or 1 mg of Pb(2+)/kg b.w (n=30) as lead acetate solution in sterile normal saline ip for a period of 4 weeks. The ip injections were then withdrawn and lead exposed rats were randomly divided into five equal groups. Six lead-exposed rats were given no treatment during the 5th week (Pb group) to serve as positive controls. The rest four groups received either ascorbic acid, alpha tocopherol or L-methionine in the 5th week at the daily dose of 100 mg/kg b.w orally or alpha tocopherol as above plus CaNa2 EDTA at the rate of 110 mg/kg b.w twice a day ip for a period of 4 days. All the animals were sacrificed 1 day after the end of the experiment, and the liver, kidney and brain were quickly excised for the estimation of lead burden and alterat...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jan 29, 1979·Life Sciences·R A Goyer, M G Cherian
Aug 22, 1977·Biochemical and Biophysical Research Communications·D J Reed, S Orrenius
Apr 1, 1991·The American Journal of Clinical Nutrition·L Packer
Jan 1, 1991·The British Veterinary Journal·D J Humphreys
Jan 1, 1990·Annual Review of Pharmacology and Toxicology·D J Reed
May 1, 1986·Acta Pharmacologica Et Toxicologica·S J Flora, S K Tandon
Mar 1, 1970·Analytical Biochemistry·G CohenJ Marcus
Jan 1, 1981·Current Topics in Cellular Regulation·A Meister
Nov 1, 1984·The Journal of Nutrition·T K Leeming, W E Donaldson
Sep 1, 1983·Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association·R LauwerysJ Konings
Jun 1, 1995·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·D P JonesS T Omaye
May 1, 1995·Toxicology and Applied Pharmacology·L Tian, D A Lawrence
Aug 1, 1994·Nutrition Reviews·B Halliwell
Jul 1, 1994·The Proceedings of the Nutrition Society·G W Burton
Mar 1, 1994·Neurochemical Research·M CiniA Moretti
Feb 21, 1998·Ecotoxicology and Environmental Safety·D R JubergS C Kwon
May 5, 1999·Neurochemical Research·J BresslerG Goldstein
Jun 9, 1999·Mechanisms of Ageing and Development·R L LevineE R Stadtman
Aug 27, 1999·Toxicology·V N Adonaylo, P I Oteiza

❮ Previous
Next ❯

Citations

May 1, 2004·Environmental Health and Preventive Medicine·Taro YamashitaMakoto Uchino
May 7, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Pu HuDi-Yun Ruan
Jan 11, 2008·Biological Trace Element Research·Iwona BłaszczykEwa Birkner
Nov 11, 2009·Biological Trace Element Research·Lin WangZongping Liu
Mar 23, 2010·Biological Trace Element Research·Iwona BłaszczykSławomir Kasperczyk
Aug 14, 2010·Biological Trace Element Research·Ahmad Ghanizadeh
Oct 21, 2010·Biological Trace Element Research·Ahmed E Abdel-MoneimSaleh Al-Quraishy
Nov 24, 2011·Biological Trace Element Research·Jicang WangXuezhong Liu
Jun 2, 2010·Journal of Physiology and Biochemistry·Enas A HamedNashwa A Abd El-Mottaleb
Sep 13, 2013·Environmental Toxicology and Pharmacology·Rita Cerejeira MatosBruno Nunes
Nov 5, 2013·Environmental Toxicology and Pharmacology·Shujun DaiWei Zhang
Sep 27, 2002·Toxicology·Ping-Chi Hsu, Yueliang Leon Guo
Jan 1, 2003·Environmental Toxicology and Pharmacology·Usha R AcharyaMonalisa Mishra
Jan 29, 2003·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·H M MousaS A ElMougy
Jul 10, 2003·Journal of Toxicology and Environmental Health. Part a·Rafael MateoAntonio Ramis
Aug 4, 2011·Journal of Toxicology·Yolanda Alcaraz-ContrerasXóchitl Sofía Ramírez-Gómez
Mar 10, 2012·PloS One·Ling WangYu-Feng Wang
Sep 18, 2008·Arhiv za higijenu rada i toksikologiju·Imran Khan MohammadVenkatesh Thuppil
Jan 1, 2008·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Omar KharoubiAbdelkader Aoues
Jan 1, 2012·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·K RehmanT A Sherazi
Feb 25, 2014·Environmental Toxicology and Pharmacology·Adela-Leonor Rendón-RamírezJosé-Víctor Calderón-Salinas
May 8, 2014·Journal of Food Science and Technology·Y Amarnath ReddyP Indira
May 7, 2011·Veterinary Medicine International·R C PatraD Swarup
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Jong Rok LeeSang Chan Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.