PMID: 8986452Dec 1, 1996Paper

Antioxidant effects of calcium antagonists on rat myocardial membrane lipid peroxidation

Hypertension Research : Official Journal of the Japanese Society of Hypertension
H SugawaraK Kikuchi

Abstract

We studied the antioxidant effects of nine calcium antagonists (nisoldipine, benidipine, nilvadipine, felodipine, nicardipine, nitrendipine, nifedipine, verapamil, and diltiazem) by means of rat myocardial membrane lipid peroxidation with a nonenzymatic active oxygen-generating system (DHF/FeCl3-ADP). The order of antioxidant potency of these agents was nilvadipine > nisoldipine > felodipine > nicardipine > verapamil > benidipine. Their IC50 values (microM) were 25.1, 28.2, 42.0, 150.0, 266.1, and 420.0, respectively. In contrast, nitrendipine, nifedipine, and diltiazem had little inhibitory effect on lipid peroxidation. These six calcium antagonists could be divided into four types on the basis of their antioxidant mechanisms. Nilvadipine, nisoldipine, and verapamil, which showed antioxidant effects both before and after the addition of active oxygen, and reduced the dihydroxyfumarate (DHF) auto-oxidation rate, were chain-breaking and preventive antioxidants. Felodipine, which showed antioxidant effects both before and after exposure to active oxygen and increased the DHF auto-oxidation rate, was only a chain-breaking antioxidant. Nicardipine, which showed an antioxidant effect only before exposure to active oxygen and reduced...Continue Reading

Citations

May 23, 2014·Toxicology and Applied Pharmacology·David Galvis-ParejaSergio Lavandero
Dec 3, 2013·European Journal of Pharmacology·Chihiro Mayama
Aug 21, 2013·Environmental Toxicology and Pharmacology·Hardik GandhiRamachandran Balaraman
Dec 10, 1999·Renal Failure·E N Wardle
Oct 12, 2010·Progress in Retinal and Eye Research·Makoto Araie, Chihiro Mayama
Nov 9, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yasumasa IwasakiNobuo Nakashima
May 24, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yoshitaka HirookaKenji Sunagawa
Jul 24, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Young-Keun OnYoung-Bae Park
Jul 24, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Naoyuki HasebeUNKNOWN Angiographical Study in Angina with Hypertension Induced Insults (ASAHI) Investigators
Mar 25, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hironobu SanadaTsuyoshi Watanabe
Oct 28, 2003·Journal of Pharmacological Sciences·Katsunori IwasakiMichihiro Fujiwara
Apr 6, 2007·Biological & Pharmaceutical Bulletin·Katsunori IwasakiMichihiro Fujiwara
Mar 11, 2003·The Journal of Pharmacy and Pharmacology·Kozo YaoTetsuji Ohno
Feb 8, 2011·Chemical & Pharmaceutical Bulletin·Yuya HorinouchiToshiaki Tamaki
Dec 3, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Iveta GasparovaPeter Kruzliak
Jun 21, 2018·Molecular and Cellular Biochemistry·Nina SimonovicVladimir Zivkovic

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