Antioxidant Effects of Probiotics in Experimentally Induced Peritonitis

Surgical Infections
Basak ErginelTansu Salman

Abstract

An experimental study was performed to evaluate the protective effects of probiotics on gut mucosa in peritonitis through antioxidant mechanisms. Thirty-two male Wistar albino rats were divided equally into four groups. The rats in Group 1 (control group) underwent laparotomy only. In group 2 (peritonitis group), peritonitis was induced in the rats by the cecal ligation and puncture (CLP) model. In group 3, the rats were treated with probiotics for five days after CLP-induced peritonitis. The last group of rats (group 4) were fed probiotics for five days before the CLP procedure and five days after the surgery. On the fifth day after surgery, all rats were killed, and tissue samples from the terminal ileum were obtained to evaluate the activities of myeloperoxidase (MPO), malondialdehyde (MDA), and glutathione (GSH). Histopathologic examinations were also performed to evaluate the grade of intestinal injury. Myeloperoxidase and MDA activities were increased, GSH concentrations were decreased in group 2, compared with group 1. Intestinal MPO activities in group 4 were decreased compared with group 1 and group 2, indicating a reduction in oxidant activity. Malondialdehyde decreased in group 3 and decreased even more in group 4, c...Continue Reading

References

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Citations

Dec 12, 2019·Anti-cancer Agents in Medicinal Chemistry·Deepa NegiNeeraj Mishra
Aug 30, 2018·Revista brasileira de enfermagem·Carolina Ferreira VascoMaria de Fátima Fernandes Vattimo
Mar 14, 2017·Oxidative Medicine and Cellular Longevity·Paulina Kleniewska, Rafał Pawliczak

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