Antioxidant effects of some drugs on immobilization stress combined with cold restraint stress.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Mira PopovicMatilda Vojnović

Abstract

The aim of this work was to investigate the effect on antioxidant potential of some commonly used drugs (morphine, tramadol, bromocriptine, haloperidol and azithromycin) on immobilization stress (IS) combined with cold restraint stress (CRS) in the rat. After the drug treatment the animals were kept immobilized in the cold chamber at 4+/-0.3 degrees C for 3 hours and then decapitaed and the livers were extracted. The following parameters were determined in the liver homogenate: content of reduced glutathione, activities of catalase, xanthine oxidase, glutathione reductase, glutathione peroxidase, peroxidase, and lipid peroxidation intensity. A battery of biochemical assays was used and the resulting data were statistically analyzed. Combined stress exhibited a prooxidative action (increased catalase activity, lowered content of reduced glutathione). Significantly enhanced catalase activity that was observed in all groups compared to the control indicates that the primary reactive oxygen species (ROS) metabolite is hydrogen peroxide, which decomposes very rapidly (very high catalase activity), thus hindering formation of OH radicals as the most toxic ROS. None of the tested drugs showed a protective effect on combined IS and CRS...Continue Reading

Citations

Mar 5, 2016·Biochemistry Research International·Emmanuel Oluwafemi Ibukun, Gideon Oludare Oladipo
Oct 18, 2016·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·M EsrefogluB Ates
May 6, 2020·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Amany Mohamed ShalabyDina Fouad El Shaer
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