PMID: 11918278Mar 29, 2002Paper

Antioxidant enzymes and paraoxonase show a co-activity in preserving low-density lipoprotein from oxidation

Clinical and Experimental Medicine
E Y SözmenB Ersöz

Abstract

Oxidative modification of low-density lipoprotein in the artery wall plays a crucial role in the development of atherosclerosis. This physiopathological mechanism is clearly inhibited by high-density lipoprotein possibly via paraoxonase enzyme activity, present in high-density lipoprotein. In this study, we determined the in vitro susceptibility of low-density lipoprotein to oxidation and the effect of various factors, such as paraoxonase phenotypes, on this process. Low-density lipoprotein from healthy volunteers (n=66) was isolated using the precipitant reagent and the oxidation was evaluated by measuring the malonyl dialdehyde and diene levels. Low-density lipoprotein cholesterol and phospholipid, vitamin E, serum cholesterol, high-density lipoprotein and low-density lipoprotein cholesterol levels, and erythrocyte antioxidant enzymes were also determined. There was no difference among the parameters with regard to gender. Low-density lipoprotein samples obtained from subjects with the AA allele were more prone to oxidation, as observed by their higher stimulated conjugated diene (P=0.041) and thiobarbituric acid-related substance (P=0.042) levels, than samples from subjects with AB or BB alleles. The subjects with the BB all...Continue Reading

Citations

Feb 18, 2004·The Journal of Laboratory and Clinical Medicine·Patrizia FabbiSilvano Garibaldi
Sep 6, 2003·International Journal of Cardiology·Elif AzarsizEser Yildirim Sözmen
Jul 27, 2007·Journal of Medicinal Food·Ebru Demirel SezerEser Yildirim Sözmen
Jul 7, 2011·Vascular Health and Risk Management·Ebru Demirel SezerTaner Onat
Jun 21, 2011·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Waleed Samy, Mohammed A Hassanian
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Jun 7, 2003·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Stefano BiasioliAntonio Fasolin
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Dec 2, 2021·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Kübra ÇelikMeral Baka

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