Antioxidant enzymes and redox regulating thiol proteins in malignancies of human lung

FEBS Letters
Vuokko L KinnulaYlermi Soini

Abstract

Oxidants are known to modulate cell proliferation and apoptosis, and induce synthesis of growth factors that play an important role in tumor growth and invasion. Antioxidant enzymes and thiol proteins regulating cellular redox state constitute the major cellular protection against oxidants. Consequently, they are also associated both with carcinogenesis and tumor progression. Superoxide dismutases, glutamate cysteine ligase, catalase, thioredoxins and peroxiredoxins, which are the most important of these enzymes, are expressed in lung malignancies, and especially in pleural mesothelioma. This has consequences not only for tumor behavior but also for resistance of tumor cells to cytotoxic drugs and radiation.

References

Nov 1, 1992·Trends in Biochemical Sciences·T Ishikawa
May 28, 1992·International Journal of Cancer. Journal International Du Cancer·A BravardB Dutrillaux
Aug 2, 1989·Journal of the National Cancer Institute·S L LaiA F Gazdar
Dec 1, 1985·Environmental Health Perspectives·D F Church, W A Pryor
Jul 1, 1987·Journal of Applied Physiology·A M CantinR G Crystal
Apr 1, 1995·Free Radical Biology & Medicine·R H Burdon
Jun 30, 1994·Biochemical and Biophysical Research Communications·H T KimG Jung
Jun 5, 1996·Cancer Letters·G GünerU Açikel
Jan 1, 1996·Free Radical Biology & Medicine·K A MarshallB Halliwell
Jan 1, 1996·Free Radical Biology & Medicine·Y Sun, L W Oberley
Jan 1, 1996·Free Radical Biology & Medicine·V L KinnulaK Linnainmaa
Mar 19, 1997·Cancer Letters·D Kromhout, H B Bueno-de-Mesquita
May 2, 1998·American Journal of Respiratory Cell and Molecular Biology·K KahlosV L Kinnula
Oct 29, 1998·British Journal of Cancer·A M JanssenH W Verspaget
Nov 24, 1999·Free Radical Biology & Medicine·D Keppler
Dec 22, 1999·Biochemical Pharmacology·C MéplanP Hainaut
Feb 19, 2000·Biochemical and Biophysical Research Communications·Y ZhouD Y Jin
Mar 29, 2000·British Journal of Cancer·K KahlosV L Kinnula
Aug 17, 2000·Journal of the National Cancer Institute·P BorstJ Wijnholds
Aug 22, 2000·Oncogene·N S ChandelP T Schumacker
Aug 30, 2000·International Journal of Cancer. Journal International Du Cancer·K KahlosV L Kinnula
Sep 30, 2000·European Journal of Biochemistry·E S Arnér, A Holmgren
Oct 18, 2000·FEBS Letters·B H RihnG D Leikauf
Feb 24, 2001·Antioxidants & Redox Signaling·A Holmgren
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·G Powis, W R Montfort
May 24, 2001·Archives of Biochemistry and Biophysics·L ForsbergR Morgenstern
Nov 6, 2001·American Journal of Respiratory Cell and Molecular Biology·K B Adler, Y Li
Nov 8, 2001·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Y SoiniV Kinnula
Dec 6, 2001·Journal of the National Cancer Institute·L I WangD C Christiani
Feb 2, 2002·Science·David LandoMurray L Whitelaw
Feb 19, 2002·Cancer Letters·Ari HirvonenVuokko Kinnula
Feb 22, 2002·The Journal of Pathology·Vuokko L KinnulaY Soini

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Citations

Nov 13, 2009·Bulletin of Experimental Biology and Medicine·R N BelonogovA A Pokrovskii
Jan 8, 2008·Antioxidants & Redox Signaling·Vuokko L Kinnula, Marjukka Myllärniemi
Mar 8, 2011·Antioxidants & Redox Signaling·Risa MaedaTakashi Nakano
Aug 19, 2008·Molecular Cancer Research : MCR·Terry A Brown-BryanCarlos A Casiano
Oct 7, 2008·World Journal of Gastroenterology : WJG·Wei LiBing-Ya Liu
Dec 17, 2009·Redox Report : Communications in Free Radical Research·Bridget WalshShelley A Phelan
Feb 5, 2008·Journal of Toxicology and Environmental Health. Part a·Nai-Yu XuJian Tong
Jan 23, 2014·Journal of Cancer Research and Clinical Oncology·Leonardo Lisbôa da MottaFábio Klamt
Nov 16, 2011·International Journal of Proteomics·C Y X'avia ChanK W Michael Siu
May 7, 2005·FEBS Letters·Jong Wook ChangYung Joon Yoo
Oct 12, 2014·Journal of Proteomics·Azeddine BentaibPierre Leprince
Aug 7, 2008·Chest·Eric KipnisJeanine Wiener-Kronish
May 15, 2012·Free Radical Biology & Medicine·Chiara RigantiDario Ghigo
Sep 20, 2011·European Journal of Internal Medicine·T KontakiotisD Papakosta
Aug 4, 2015·Digestive Diseases and Sciences·A E GordeevaV I Novoselov
May 27, 2006·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Y SoiniV L Kinnula
May 9, 2006·Biochemical and Biophysical Research Communications·Jong Wook ChangYung Joon Yoo
Apr 1, 2006·Blood Cells, Molecules & Diseases·Angel Hernández-HernándezJesús Sánchez-Yagüe
Apr 4, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Massod Mashhadi Akbar Boojar, Faranak Goodarzi
Jul 11, 2013·BioMed Research International·Mehmet Ibrahim TuranAbdullah Kisaoglu
Apr 10, 2012·Physiology & Behavior·Marina de Lima MarcolinCarla Dalmaz
Sep 18, 2010·The Biochemical Journal·Carsten BerndtUlf T Brunk
Mar 14, 2014·Redox Biology·Brian CunniffNicholas H Heintz
Nov 8, 2011·Journal of Proteome Research·Steffen OhlmeierVuokko L Kinnula
Sep 7, 2016·International Journal of Molecular Sciences·Kun ChunSang-Han Lee
Oct 30, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Taylor RohMyeong Jin Nam

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