Antioxidant enzymes, presbycusis, and ethnic variability.

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Anthony BaredXue Zhong Liu

Abstract

A proposed mechanism for presbycusis is a significant increase in oxidative stress in the cochlea. The enzymes glutathione S-transferase (GST) and N-acetyltransferase (NAT) are two classes of antioxidant enzymes active in the cochlea. In this work, we sought to investigate the association of different polymorphisms of GSTM1, GSTT1, and NAT2 and presbycusis and analyze whether ethnicity has an effect in the genotype-phenotype associations. Case-control study of 134 DNA samples. University-based tertiary care center. Clinical, audiometric, and DNA testing of 55 adults with presbycusis and 79 control patients with normal hearing. The GSTM1 null genotype was present in 77 percent of white Hispanics and 51 percent of white non-Hispanics (Fisher's exact test, 2-tail, P = 0.0262). The GSTT1 null genotype was present in 34 percent of control patients and in 60 percent of white presbycusis subjects (P = 0.0067, odds ratio [OR] = 2.843, 95% confidence interval [95% CI] = 1.379-5.860). The GSTM1 null genotype was more frequent in presbycusis subjects, i.e., 48 percent of control patients and 69 percent of white subjects carried this deletion (P = 0.0198, OR = 2.43, 95% CI = 1.163-5.067). The NAT2*6A mutant genotype was more frequent among...Continue Reading

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Citations

Feb 18, 2014·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Erol KeleşSinasi Yalcın
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Apr 8, 2020·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Ning-Chia ChangKuen-Yao Ho
Jan 18, 2020·Journal of Clinical Medicine·Jing Wang, Jean-Luc Puel
Feb 12, 2020·Experimental Gerontology·Hyo-Jin ParkShinichi Someya
May 1, 2021·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Ning-Chia ChangKuen-Yao Ho
Jul 3, 2021·Frontiers in Cellular Neuroscience·Xiaolong FuRenjie Chai

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Methods Mentioned

BETA
PCR

Software Mentioned

JMP IN

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