Antioxidant, free radical-scavenging activity and cytotoxicity of different solvent extracts and their phenolic constituents from the fruit hull of mangosteen (Garcinia mangostana)

Pharmaceutical Biology
Tanasait NgawhirunpatIsao Adachi

Abstract

Antioxidative, skin protective activities, and cytotoxicity of three extracts (water, methanol, and hexane) from the fruit hull of mangosteen (Garcinia mangostana Linn. (Guttiferae)) and their phenolic constituents such as alpha-mangostin, epicatechin, and tannin, were evaluated. The amounts of alpha-mangostin, total flavonoid, and total tannin were different among the three extracts, except those of total tannin in methanol and hexane extracts. For the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free-radical scavenging, hydroxyl radical-scavenging, and inhibition of lipid peroxidation experiment, the water extract showed higher activity than the methanol extract and hexane extract. alpha-Mangostin, epicatechin, and tannin also revealed these antioxidant and free radical-scavenging activities. When added simultaneously with H(2)O(2) (200 microM) to keratinocyte cells, the water extract (50 microg/mL), epicatechin (200 microM), and tannin (200 microM) effectively protected cells from oxidative damage, but the methanol extract, hexane extract, and alpha-mangostin did not. The methanol extract and hexane extract exhibited moderate cytotoxicity, whereas alpha-mangostin showed strong cytotoxicity. The present study provides the evidence th...Continue Reading

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Citations

Mar 9, 2012·The Journal of Nutrition·Chureeporn ChitchumroonchokchaiMark L Failla
Aug 4, 2015·Journal of Clinical Biochemistry and Nutrition·Rei-Ichi OhnoRyoji Nagai
Mar 20, 2014·The Journal of Pharmacy and Pharmacology·Primchanien MoongkarndiNarongchai Pongpan
Apr 4, 2015·Experimental Parasitology·Ratchadawan AukkanimartSirintip Boonjaraspinyo
Aug 23, 2011·Food Research International·Samir DevalarajaHariom Yadav
May 3, 2015·Annales pharmaceutiques françaises·M A SmachK Limem
Nov 9, 2017·Investigational New Drugs·Daniel SypniewskiIlona Bednarek
Feb 20, 2021·European Journal of Pharmacology·Aihong YangRui Shen
Sep 8, 2010·Bioorganic & Medicinal Chemistry Letters·He Zhong JiangYou Xing Zhao

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