PMID: 19942803Nov 28, 2009Paper

Antioxidant, free radical-scavenging, and NF-kappaB-inhibitory activities of phytosteryl ferulates: structure-activity studies

Journal of Pharmacological Sciences
Md Shafiqul IslamHiroshi Ozaki

Abstract

Some of the pharmacological properties of phytosteryl ferulates may be linked to their antioxidant potential. In this study, 2,2-diphenyl-1-picrylhydrazyl (DPPH), electron spin resonance (ESR), and thiobarbituric acid-reactive substances (TBARS) assays demonstrated that phytosteryl ferulates such as cycloartenyl ferulate (CAF), 24-methylenecycloartanyl ferulate (24-mCAF), and beta-sitosteryl ferulate (beta-SF) and ferulic acid (FA) each exerted strong free radical scavenging and antioxidation of lipid membrane, which were comparable to alpha-tocopherol. However, the sterol moiety alone, such as cycloartenol (CA), had neither activity. Since, the reactive oxygen species (ROS) production in the cell complex defense mechanism cannot be ruled out with the cell free system, we measured ROS production in NIH 3T3 fibroblast cells induced by H(2)O(2). CAF and ethyl ferulate (eFA) greatly decreased the ROS level in this system. CA also significantly inhibited the ROS level, suggesting that CA could inhibit ROS production in living cells. Besides these, CAF, 24-mCAF, beta-SF, as well as eFA and CA, all these chemicals significantly inhibited the NF-kappaB activity as analyzed by measuring translocation of NF-kappaB p65 in LPS-stimulated ...Continue Reading

References

Oct 1, 1995·Free Radical Biology & Medicine·T ParasassiE Gratton
May 1, 1995·Bioscience, Biotechnology, and Biochemistry·S J KimJ S Rhee
Jan 1, 1996·Free Radical Biology & Medicine·C A Rice-EvansG Paganga
Feb 7, 1998·The Journal of Clinical Investigation·F R DeLeoW M Nauseef
Dec 20, 1999·Journal of Agricultural and Food Chemistry·Z Xu, J S Godber
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·N S ChandelP T Schumacker
Jul 11, 2000·Journal of Agricultural and Food Chemistry·T AkihisaK Arai
Sep 26, 2000·Molecular Genetics and Metabolism·C T D'Angio, J N Finkelstein
Oct 26, 2000·Trends in Biochemical Sciences·S Raha, B H Robinson
Feb 22, 2001·Free Radical Biology & Medicine·D K KimH D Um
Mar 10, 2001·Nutrition·L Castro, B A Freeman
Jan 5, 2002·Physiological Reviews·Wulf Dröge
Apr 30, 2003·The Journal of Biological Chemistry·Frances LebronAndrew H Limper
Jun 14, 2003·Redox Report : Communications in Free Radical Research·Sarwat SultanaSonia Sharma
Feb 3, 2005·Journal of Agricultural and Food Chemistry·Seok Hyun NamMendel Friedman
Mar 31, 2005·Journal of Agricultural and Food Chemistry·Laura NyströmVieno Piironen
Jul 12, 2005·International Journal of Pharmaceutics·Claudia JulianoLuisella Piu
Aug 30, 2005·Mutation Research·M A SoobratteeT Bahorun
Sep 22, 2005·Nature Reviews. Immunology·Michael Karin, Florian R Greten
Jan 18, 2006·Life Sciences·Radha K MaheshwariRikhab C Srimal
Oct 13, 2006·Bioscience, Biotechnology, and Biochemistry·Wen-Hsin HuangChing-Huey Yang
Feb 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrey Y AbramovMichael R Duchen
May 15, 2007·Biochemical and Biophysical Research Communications·Reiko NagasakaHideki Ushio
Jun 19, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Takako YokozawaGen-Ichiro Nonaka
Feb 1, 2008·Phytotherapy Research : PTR·Peter C Dartsch
Apr 15, 2008·Chemico-biological Interactions·L Pari, A Prasath
Apr 22, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Chatchawan Chotimarkorn, Hideki Ushio
May 1, 2008·Molecular Cancer Therapeutics·Komal RainaChapla Agarwal
May 14, 2008·Journal of Agricultural and Food Chemistry·Josip MastelićNorbert Müller

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Citations

Sep 29, 2011·Lasers in Medical Science·Chin-Hsien ChangYen-Lin Chang
Jun 6, 2013·Journal of Medicinal Food·Ana Paula de Oliveira BarbosaMárcio Roberto Viana dos Santos
Jun 8, 2012·The Journal of Veterinary Medical Science·Kampon KaeoketPanida Chanapiwat
Aug 27, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Simón NavarreteIván Palomo
Jun 19, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ana C NazaréValdecir F Ximenes
Jan 21, 2016·Journal of Natural Products·Dan ZhuLaura Nyström
Oct 27, 2015·Naunyn-Schmiedeberg's Archives of Pharmacology·Francisco Valmor Macedo CunhaFrancisco de Assis Oliveira
Feb 12, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Reiko NagasakaHideki Ushio
Jan 13, 2011·Expert Opinion on Pharmacotherapy·Kanwaljit ChopraAnurag Kuhad
Jul 30, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Y-Y KouR-L Li
Apr 29, 2015·The American Journal of Chinese Medicine·Yanhong SiLinlin Gao
Nov 7, 2014·International Journal of Food Sciences and Nutrition·Heon Woong KimKyung-A Hwang
Jun 22, 2010·Journal of Pharmacological Sciences·Yoshiki TsubosakaHiroshi Ozaki
Aug 16, 2016·International Journal of Molecular Sciences·Igor Otavio MinatelGiuseppina Pace Pereira Lima
Jul 8, 2017·Journal of Medicinal Food·Soon Young ShinYoung Han Lee
Mar 14, 2018·Nutrition Reviews·Ewelina KurtysErik F J de Vries
Mar 7, 2019·Dermatitis : Contact, Atopic, Occupational, Drug·Melody MaaroufVivian Y Shi
Feb 27, 2019·Current Pharmaceutical Biotechnology·Isabel Sánchez-CrisóstomoRosa A Bobadilla-Lugo
Jan 17, 2020·Journal of Food Science·Dan LiDong-Jie Zhang
Aug 26, 2020·Scientific Reports·Halida RahmaniaKiyotaka Nakagawa
May 17, 2019·Dermatitis : Contact, Atopic, Occupational, Drug·Melody MaaroufVivian Y Shi
Oct 15, 2014·Asian Pacific Journal of Tropical Medicine·Nguyen Thi Mai PhuongDang Ngoc Quang
Jan 27, 2019·Expert Opinion on Therapeutic Patents·Francisco Valmor Macedo CunhaLívio César Cunha Nunes
Jul 23, 2011·Journal of Separation Science·Apostolis AngelisAlexios-Leandros Skaltsounis
Feb 27, 2021·Drug and Chemical Toxicology·Camila Bomfim de SáMargareth de Fátima Formiga Melo Diniz
Nov 5, 2021·Journal of Oleo Science·Afroza SultanaMd Alauddin
Jan 24, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·So-Youn MokSanghyun Lee

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