Antioxidant icariside II combined with insulin restores erectile function in streptozotocin-induced type 1 diabetic rats

Journal of Cellular and Molecular Medicine
Lin WangZhongcheng Xin

Abstract

Erectile dysfunction (ED) worsens in patients with diabetes mellitus (DM) despite good control of blood glucose level with insulin. Recent studies imply that diabetic vascular stresses (e.g. oxidative stress) persist in spite of glucose normalization, which is defined as metabolic memory. Studies suggest that the interaction between advanced glycation end products (AGEs) and their receptor (RAGE) mediates the development of metabolic memory. To investigate the effects of the antioxidant icariside II plus insulin on erectile function in streptozotocin (STZ)- induced type 1 diabetic rats. Fifty 8-week-old Sprague-Dawley rats were randomly distributed into five groups: normal control, diabetic, insulin-treated diabetic, icariside II-treated diabetic, and insulin plus icariside II-treated diabetic. Diabetes was induced by a single intraperitoneal injection of STZ. Eight weeks after induction of diabetes, icariside II was administered by gastric lavage once a day (5 mg/kg) for 6 weeks; and 2-6 units of intermediate-acting insulin were given to maintain normal glycemia for 6 weeks. The main outcome measures were the ratio of intracavernous pressure (ICP) to mean arterial pressure (MAP); histology of penile endothelial cells and smoot...Continue Reading

References

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Citations

Feb 18, 2016·Nature Reviews. Urology·Ângela Castela, Carla Costa
Nov 5, 2015·The Journal of Sexual Medicine·Tao CuiRyan P Terlecki
Oct 9, 2015·The Tohoku Journal of Experimental Medicine·Jiaming WenNan Zhang
Aug 22, 2016·Sexual Medicine Reviews·Fuat KizilayEge Can Serefoglu
Aug 15, 2018·Expert Opinion on Pharmacotherapy·Ahmed I El-Sakka
Sep 23, 2018·International Urology and Nephrology·Jiang-Lei ZhangJian-Quan Hou
Jul 3, 2021·Journal of Clinical Medicine·Angelo CignarelliFrancesco Giorgino

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Methods Mentioned

BETA
lavage
Protein Assay
electrophoresis
MDA

Software Mentioned

Prism
Image J

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