Antioxidant lazaroid U-74006F improves renal function and reduces the expression of cytokines, inducible nitric oxide synthase, and MHC antigens in a syngeneic renal transplant model. Partial support for the response-to-injury hypothesis

Transplantation
A SalahudeenH Barber

Abstract

In a recent study, antioxidant therapy at the time of renal transplantation in humans was associated with fewer rejection episodes and extended graft survival. A hypothesis generated by such studies and based on the response-to-injury model is that reducing the oxidative injury during transplantation may dampen certain cellular responses to injury that are important in triggering allograft rejection. To test whether ablation of oxidative injury would limit such responses, kidneys were transplanted between Wistar-Furth rats, with and without antioxidant 21-aminosteroid. 21-Aminosteroid was administered before kidney harvest and, again, before transplant reperfusion. The recipient's left kidneys, removed to accommodate the donor kidneys, were used as normal control. The removal of the right kidneys contralateral to the transplant were delayed to day 4 to provide interim renal support. The transplanted kidneys were harvested on day 7. Administration of 21-aminosteroid was associated with better graft function and reduced lipid peroxidation. Compared with the normal control kidneys, the kidneys transplanted with vehicle had higher cytokine mRNA levels (measured by reverse transcriptase-polymerase chain reaction) for interleukin 2, ...Continue Reading

References

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Citations

Nov 30, 2000·Anesthesiology Clinics of North America·S Garwood
Dec 2, 2004·Canadian Journal of Physiology and Pharmacology·Farzad Moien-AfshariIsmail Laher
Aug 31, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Hong Huang, Abdulla K Salahudeen
Nov 7, 1998·British Journal of Pharmacology·L LecanuM Plotkine
Jan 14, 2004·Kidney International·Abdulla K SalahudeenWarren May
Nov 26, 2010·The Journal of Surgical Research·Ioannis I FlessasGeorge C Zografos
Jan 17, 2002·The Urologic Clinics of North America·D A ShoskesS Kim
Nov 5, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L K KaylerJ D Schold
Sep 13, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L K KaylerJ D Schold
Feb 24, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·H HuangA K Salahudeen
Dec 16, 2000·Transplantation·A K SalahudeenJ K Jenkins
Dec 10, 1999·Renal Failure·E N Wardle
Jul 24, 2004·American Journal of Physiology. Renal Physiology·Abdulla K Salahudeen
Jun 17, 1999·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·S HillingerW Weder

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