Overproduction of oxidants (reactive oxygen species and reactive nitrogen species) in the human body is responsible for the pathogenesis of some diseases. The scavenging of these oxidants is thought to be an effective measure to depress the level of oxidative stress of organisms. It has been reported that intake of vegetables and fruits is inversely associated with the risk of many chronic diseases, and antioxidant phytochemicals in vegetables and fruits are considered to be responsible for these health benefits. Antioxidant phytochemicals can be found in many foods and medicinal plants, and play an important role in the prevention and treatment of chronic diseases caused by oxidative stress. They often possess strong antioxidant and free radical scavenging abilities, as well as anti-inflammatory action, which are also the basis of other bioactivities and health benefits, such as anticancer, anti-aging, and protective action for cardiovascular diseases, diabetes mellitus, obesity and neurodegenerative diseases. This review summarizes recent progress on the health benefits of antioxidant phytochemicals, and discusses their potential mechanisms in the prevention and treatment of chronic diseases.
Increases in human plasma antioxidant capacity after consumption of controlled diets high in fruit and vegetables
Serum antioxidant capacity is increased by consumption of strawberries, spinach, red wine or vitamin C in elderly women
Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals
Multivitamin-multimineral supplements and eye disease: age-related macular degeneration and cataract
Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis
Protective effect of quercetin in primary neurons against Abeta(1-42): relevance to Alzheimer's disease.
Effect of antioxidant phytochemicals on the hepatic tumor promoting activity of 3,3',4,4'-tetrachlorobiphenyl (PCB-77).
Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers
Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms.
Supramolecular phospholipids-polyphenolics interactions: the PHYTOSOME strategy to improve the bioavailability of phytochemicals
Flavonoid intake and disability-adjusted life years due to Alzheimer's and related dementias: a population-based study involving twenty-three developed countries
Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice
Cistaceae aqueous extracts containing ellagitannins show antioxidant and antimicrobial capacity, and cytotoxic activity against human cancer cells
Polyphenols enhance total oxidant-scavenging capacities of human blood by binding to red blood cells
A new high-performance liquid chromatographic method for the determination and distribution of linalool in Michelia alba.
Screening of natural antioxidants from traditional Chinese medicinal plants associated with treatment of rheumatic disease
Butein from Rhus verniciflua protects pancreatic β cells against cytokine-induced toxicity mediated by inhibition of nitric oxide formation
Histological and immunohistochemical evaluation of the chemopreventive role of lycopene in tongue carcinogenesis induced by 4-nitroquinoline-1-oxide
Frequency of citrus fruit intake is associated with the incidence of cardiovascular disease: the Jichi Medical School cohort study
Potential mechanisms by which polyphenol-rich grapes prevent obesity-mediated inflammation and metabolic diseases
Inhibition of ulcerative colitis in mice after oral administration of a polyphenol-enriched cocoa extract is mediated by the inhibition of STAT1 and STAT3 phosphorylation in colon cells
Lycopene enhances antioxidant enzyme activities and immunity function in N-methyl-N'-nitro-N-nitrosoguanidine-enduced gastric cancer rats.
Consumption of lycopene inhibits the growth and progression of colon cancer in a mouse xenograft model
Synergistic anticancer activity of curcumin and catechin: an in vitro study using human cancer cell lines
Seasonal variation of phenolic antioxidant-mediated α-glucosidase inhibition of Ascophyllum nodosum.
Phenolic acids are in vivo atheroprotective compounds appearing in the serum of rats after blueberry consumption
Flavonol kaempferol improves chronic hyperglycemia-impaired pancreatic beta-cell viability and insulin secretory function
Natural remedies used by Bunong people in Mondulkiri province (Northeast Cambodia) with special reference to the treatment of 11 most common ailments
Association between high consumption of phytochemical-rich foods and anthropometric measures: a systematic review
Ultrasound-Assisted Extraction and Identification of Natural Antioxidants from the Fruit of Melastoma sanguineum Sims
Combined Effects of Curcumin and Lycopene or Bixin in Yoghurt on Inhibition of LDL Oxidation and Increases in HDL and Paraoxonase Levels in Streptozotocin-Diabetic Rats
Combination Treatments with Luteolin and Fisetin Enhance Anti-Inflammatory Effects in High Glucose-Treated THP-1 Cells Through Histone Acetyltransferase/Histone Deacetylase Regulation
Silymarin exerts antifungal effects via membrane-targeted mode of action by increasing permeability and inducing oxidative stress
Assessment of silibinin as a potential antifungal agent and investigation of its mechanism of action
Molecular Approaches to Genetically Improve the Accumulation of Health-Promoting Secondary Metabolites in Staple Crops-A Case Study: The Lipoxygenase-B1 Genes and Regulation of the Carotenoid Content in Pasta Products
Health-Promoting Effects of Thymus herba-barona, Thymus pseudolanuginosus, and Thymus caespititius Decoctions
Effects of Multivitamin, Multimineral and Phytonutrient Supplementation on Nutrient Status and Biomarkers of Heart Health Risk in a Russian Population: A Randomized, Double Blind, Placebo Controlled Study
Protective mechanisms of 6-gingerol in dextran sulfate sodium-induced chronic ulcerative colitis in mice
Red raspberry decreases heart biomarkers of cardiac remodeling associated with oxidative and inflammatory stress in obese diabetic db/db mice
Dietary flavonoids as a potential intervention to improve redox balance in obesity and related co-morbidities: a review
Microwave-Assisted Extraction of Phenolic Compounds from Melastoma sanguineum Fruit: Optimization and Identification
Metabolic engineering to simultaneously activate anthocyanin and proanthocyanidin biosynthetic pathways in Nicotiana spp
Body Mass Index as a Determinant of Systemic Exposure to Gallotannin Metabolites during 6-Week Consumption of Mango (Mangifera indica L.) and Modulation of Intestinal Microbiota in Lean and Obese Individuals
Multivitamin and Mineral Supplementation Containing Phytonutrients Scavenges Reactive Oxygen Species in Healthy Subjects: A Randomized, Double-Blinded, Placebo-Controlled Trial
Targeting gut microbiota with dietary components on cancer: Effects and potential mechanisms of action
Protective effect of aminoguanidine against lipopolysaccharide-induced hepatotoxicity and liver dysfunction in rat.
The effect of vegetable and spice addition on the acrylamide content and antioxidant activity of innovative cereal products
Immunometabolism: A Multi-Omics Approach to Interpreting the Influence of Exercise and Diet on the Immune System
Effects of Maerua subcordata (Gilg) DeWolf on electrophile-responsive element (EpRE)-mediated gene expression in vitro
Role of Berry Anthocyanins and Phenolic Acids on Cell Migration and Angiogenesis: An Updated Overview
Aspergillus flavus as a Model System to Test the Biological Activity of Botanicals: An Example on Citrullus colocynthis L. Schrad. Organic Extracts
Effects of Tannase and Ultrasound Treatment on the Bioactive Compounds and Antioxidant Activity of Green Tea Extract
Phenolic Profile and Antioxidant Activity of the Edible Tree Peony Flower and Underlying Mechanisms of Preventive Effect on H2 O2 -Induced Oxidative Damage in Caco-2 Cells
Urine Metabolites and Antioxidant Effect after Oral Intake of Date (Phoenix dactylifera L .) Seeds-Based Products (Powder, Bread and Extract) by Human
Yarrow supercritical extract exerts antitumoral properties by targeting lipid metabolism in pancreatic cancer
Cocoa and unripe banana flour beverages improve anthropometric and biochemical markers in overweight women: A randomised double-blind study.
Cardiovascular Disease Pathophysiology
Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.