Antioxidant polyphenols in cancer treatment: Friend, foe or foil?

Seminars in Cancer Biology
Gian Luigi RussoMaria Russo

Abstract

Cancer prevention can be probably obtained with easier, faster and less financial strains by pursuing educational programs aimed to induce changes in lifestyle, starting from dietary habits. In the past decades, observational and case-control studies tried to establish a functional relationship between cancer mortality and morbidity and diet. The field becomes even more intricate when scientists investigated which dietary components are responsible for the putative, protective effects of fruits and vegetables against cancer. A relevant part of the literature focused on the positive role of "antioxidant" compounds in foods, including polyphenols. The present review critically evaluate clinical and pre-clinical studies based on polyphenol administration, which contributed to support the concept, deeply rooted in the general population, that antioxidant polyphenols can fight cancer. The controversial and contradictory issues related to the pros and cons on the use of polyphenols against cancer reflect the confounding assumption that cancer treatment and cancer prevention may overlap. We conclude that a clear cut must be done between these two concepts and that the experimental approaches to investigate one or the other should be s...Continue Reading

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Citations

Mar 21, 2018·Critical Reviews in Food Science and Nutrition·Dunja ŠamecBranka Salopek-Sondi
Dec 20, 2017·Frontiers in Pharmacology·Valéry L PayenPierre Sonveaux
Feb 13, 2018·Oxidative Medicine and Cellular Longevity·Maria RussoGian Luigi Russo
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Jan 21, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Veronika KhairullinaAnatoly Gerchikov
Dec 8, 2020·Neuroscience·Jotele Fontana AgostiniAlmir Gonçalves Wanderley
Jan 7, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ana Sanches-SilvaMohammad Hossein Farzaei
Dec 11, 2020·Oxidative Medicine and Cellular Longevity·Nan YangXiao-Yuan Mao
Feb 13, 2021·Antioxidants·Carmen Griñan-LisonSergio Granados-Principal
Nov 23, 2020·Environmental Science and Pollution Research International·Ajay KumarSatwinderjeet Kaur
Aug 1, 2020·Chemico-biological Interactions·Maria RussoGian Luigi Russo
Apr 1, 2021·Phytotherapy Research : PTR·Abhishek GourUtpal Nandi
May 27, 2021·International Journal of Food Science·Maria Quijano-AvilésPatricia Manzano
Jan 27, 2020·Journal of Ethnopharmacology·Carlos Fernando Araújo-LimaAndrea Furtado Macedo

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